Notch signalling: multifaceted role in development and disease

N Sachan, V Sharma, M Mutsuddi… - The FEBS …, 2024 - Wiley Online Library
Notch pathway is an evolutionarily conserved signalling system that operates to influence an
astonishing array of cell fate decisions in different developmental contexts. Notch signalling …

[HTML][HTML] Lipopolysaccharides (LPSs) as potent neurotoxic glycolipids in Alzheimer's disease (AD)

Y Zhao, VR Jaber, AI Pogue, NM Sharfman… - International Journal of …, 2022 - mdpi.com
Lipopolysaccharides (LPSs) are microbiome-derived glycolipids that are among the most
potent pro-inflammatory neurotoxins known. In Homo sapiens, the major sources of LPSs …

Targeting epigenetics: A novel promise for Alzheimer's disease treatment

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

[HTML][HTML] miR-143-3p inhibits aberrant tau phosphorylation and amyloidogenic processing of APP by directly targeting DAPK1 in Alzheimer's disease

L Wang, X Shui, Y Mei, Y Xia, G Lan, L Hu… - International Journal of …, 2022 - mdpi.com
The neuropathology of Alzheimer's disease (AD) is characterized by intracellular
aggregation of hyperphosphorylated tau and extracellular accumulation of beta-amyloid …

[HTML][HTML] Astrocytic MicroRNAs and transcription factors in Alzheimer's disease and therapeutic interventions

A Nassar, T Kodi, S Satarker, P Chowdari Gurram… - Cells, 2022 - mdpi.com
Astrocytes are important for maintaining cholesterol metabolism, glutamate uptake, and
neurotransmission. Indeed, inflammatory processes and neurodegeneration contribute to …

Discerning the prospects of miRNAs as a multi-target therapeutic and diagnostic for alzheimer's disease

D Bhatnagar, S Ladhe, D Kumar - Molecular Neurobiology, 2023 - Springer
Although over the last few decades, numerous attempts have been made to halt Alzheimer's
disease (AD) progression and mitigate its symptoms, only a few have been proven …

REGULATORY ROLES OF microRNAs IN MODULATING MITOCHONDRIAL DYNAMICS, AMYLOID BETA FIBRILLATION, MICROGLIAL ACTIVATION, AND …

M Sharma, AK Tanwar, PK Purohit, P Pal… - Neuroscience & …, 2024 - Elsevier
Alzheimer's Disease (AD) remains a formidable challenge due to its complex pathology,
notably involving mitochondrial dysfunction and dysregulated microRNA (miRNA) signaling …

[HTML][HTML] Neuronal dysfunction and gene modulation by non-coding RNA in Parkinson's disease and synucleinopathies

R Meccariello, GC Bellenchi, S Pulcrano… - Frontiers in Cellular …, 2024 - frontiersin.org
Over the last few decades, emerging evidence suggests that non-coding RNAs (ncRNAs)
including long-non-coding RNA (lncRNA), microRNA (miRNA) and circular-RNA (circRNA) …

MiR-191-5p attenuates tau phosphorylation, Aβ generation, and neuronal cell death by regulating death-associated protein kinase 1

L Wang, X Shui, M Zhang, Y Mei, Y Xia… - ACS Chemical …, 2022 - ACS Publications
Dysregulation of microRNAs has been implicated in diverse diseases, including Alzheimer's
disease (AD). MiR-191-5p in plasma/serum has been identified as a novel and promising …

Sera miR-34a, miR-29b and miR-181c as potential novel diagnostic biomarker panel for Alzheimers in the Egyptian population

NZ Abuelezz, FE Nasr, WMA Aal, T Molokhia… - Experimental …, 2022 - Elsevier
Background Till date, there is an obvious obscurity of specific and early diagnostic
biomarkers for Alzheimer's disease (AD). The promising diagnostic potential of serum …