Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

Animals living in the Southern Ocean have evolved in a singular environment. It shares
many of its attributes with the high Arctic, namely low, stable temperatures, the pervading …

Liver fibrosis represents a significant health problem worldwide of which no acceptable
therapy exists. The most characteristic feature of liver fibrosis is excess deposition of type I …

Liver fibrosis and its end-stage disease cirrhosis are major world health problems arising
from chronic injury of the liver by a variety of etiological factors including viruses, alcohol and …

Vertebrates possess multiple respiratory globins that differ in terms of structure, function, and
tissue distribution. Three types of globins have been described so far: hemoglobin facilitates …

Background and Aims During liver fibrosis, liver sinusoidal endothelial cells (LSECs)
release angiocrine signals to recruit inflammatory cells into the liver. p300, a master …

The heme in the active center of peroxidases reacts with hydrogen peroxide to form highly
reactive intermediates, which then oxidize simple substances called peroxidase substrates …