The messenger RNA processing reactions of capping, splicing, and polyadenylation occur
cotranscriptionally. They not only influence one another's efficiency and specificity, but are …

The worldwide decline in amphibians has been attributed to several causes, especially
habitat loss and disease. We identified a further factor, namely “habitat split”—defined as …

The activities of several mRNA processing factors are coupled to transcription through
binding to RNA polymerase II (Pol II). The largest subunit of Pol II contains a repetitive …

▪ Abstract L1 retrotransposons comprise 17% of the human genome. Although most L1s are
inactive, some elements remain capable of retrotransposition. L1 elements have a long …

Prostate tumors develop resistance to androgen deprivation therapy (ADT) by multiple
mechanisms, one of which is to express constitutively active androgen receptor (AR) splice …

▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …

Abstract Changes in promoter structure and occupation have been shown to modify the
splicing pattern of several genes, evidencing a coupling between transcription and …

A poly (A) tail is found at the 3 end of nearly every fully processed eukaryotic mRNA and has
been suggested to influence virtually all aspects of mRNA metabolism. Its proposed …

Pre-mRNA 3′ end formation is an essential step in eukaryotic gene expression. Over half of
human genes produce alternatively polyadenylated mRNAs, suggesting that regulated …

Gene expression in eukaryotes requires several multi-component cellular machines. Each
machine carries out a separate step in the gene expression pathway, which includes …