Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

Y Shi, H Zhang, S Huang, L Yin, F Wang… - … and Targeted Therapy, 2022 - nature.com
Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

Involvement of circRNAs in the Development of Heart Failure

G Sygitowicz, D Sitkiewicz - International Journal of Molecular Sciences, 2022 - mdpi.com
In recent years, interest in non-coding RNAs as important physiological regulators has
grown significantly. Their participation in the pathophysiology of cardiovascular diseases is …

Clinical significance of MicroRNAs, long non-coding RNAs, and CircRNAs in cardiovascular diseases

DD Singh, Y Kim, SA Choi, I Han, DK Yadav - Cells, 2023 - mdpi.com
Based on recent research, the non-coding genome is essential for controlling genes and
genetic programming during development, as well as for health and cardiovascular …

[HTML][HTML] circ‑Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS

S Sun, Q Kong, Z Cai, M Wang… - International …, 2021 - spandidos-publications.com
Pulmonary arterial hypertension is a progressive and fatal disease. Recent studies suggest
that circular RNA (circRNAs/circs) can regulate various biological processes, including cell …

Non-coding RNA-mediated gene regulation in cardiovascular disorders: current insights and future directions

M Abubakar, M Hajjaj, ZZ Naqvi, H Shanawaz… - Journal of …, 2023 - Springer
Cardiovascular diseases (CVDs) pose a significant burden on global health. Developing
effective diagnostic, therapeutic, and prognostic indicators for CVDs is critical. This narrative …

Research progress of circular RNAs in myocardial ischemia

JJ Tibenda, N Wang, N Li, Y Dang, Y Zhu, X Wang… - Life Sciences, 2024 - Elsevier
Circular RNAs (circRNAs) are a type of single-stranded RNA that forms a covalently closed
continuous loop. Its structure, stability, properties, and cell-and tissue-specificity have gained …

Circular RNAs in tuberculosis and lung cancer

S Jabeen, N Ahmed, F Rashid, N Lal, F Kong, Y Fu… - Clinica Chimica …, 2024 - Elsevier
This review signifies the role of circular RNAs (circRNAs) in tuberculosis (TB) and lung
cancer (LC), focusing on pathogenesis, diagnosis, and treatment. CircRNAs, a newly …

The role of circRNAs in the regulation of myocardial angiogenesis in coronary heart disease

X Ma, X Chen, C Mo, L Li, S Nong, C Gui - Microvascular Research, 2022 - Elsevier
During myocardial ischemia, timely reperfusion is critical to limit infarct area and the overall
loss of cardiac contractile function. New treatment strategies need to be developed for …

Current Approaches in Cardiac Repair: Somatic and Stem Cell Exosomes

SA Yuka, A Aslan - Current Treatment Options in Cardiovascular Medicine, 2023 - Springer
Abstract Purpose of Review Myocardial infarction, which is the most important clinical sign of
coronary artery disease, is one of the leading causes of global mortality, despite current …

circRNA-miRNA-mRNA networks reveal a proangiogenic action of circNPHP1 in human ischemic heart disease

M Anwar, M Sarkar, K Ford, G Angelini, P Punjabi… - bioRxiv, 2024 - biorxiv.org
Background: Ischemic heart disease (IHD) is characterized by insufficient myocardial blood
flow and aggravated by diabetes. IHD is often treated by coronary revascularization …