Efficacy of radium-223 in bone-metastatic castration-resistant prostate cancer with and without homologous repair gene defects
Background Pathogenic mutations in genes mediating homologous recombination (HR)
DNA repair are present in 20–30% of men with metastatic castrate-resistant prostate cancer …
DNA repair are present in 20–30% of men with metastatic castrate-resistant prostate cancer …
[HTML][HTML] Molecular pathways and targets in prostate cancer
Prostate cancer co-opts a unique set of cellular pathways in its initiation and progression.
The heterogeneity of prostate cancers is evident at earlier stages, and has led to rigorous …
The heterogeneity of prostate cancers is evident at earlier stages, and has led to rigorous …
Molecular mechanisms and genetic alterations in prostate cancer: From diagnosis to targeted therapy
F Fontana, M Anselmi, P Limonta - Cancer Letters, 2022 - Elsevier
Prostate cancer remains one of the most lethal malignancies among men worldwide.
Although the primary tumor can be successfully managed by surgery and radiotherapy …
Although the primary tumor can be successfully managed by surgery and radiotherapy …
DNA damage response and prostate cancer: defects, regulation and therapeutic implications
DNA damage response (DDR) includes the activation of numerous cellular activities that
prevent duplication of DNA lesions and maintain genomic integrity, which is critical for the …
prevent duplication of DNA lesions and maintain genomic integrity, which is critical for the …
Characterization of the cancer spectrum in men with germline BRCA1 and BRCA2 pathogenic variants: results from the consortium of investigators of modifiers of …
Importance The limited data on cancer phenotypes in men with germlineBRCA1 and
BRCA2pathogenic variants (PVs) have hampered the development of evidence-based …
BRCA2pathogenic variants (PVs) have hampered the development of evidence-based …
Germline genetics of prostate cancer
HM Khan, HH Cheng - The Prostate, 2022 - Wiley Online Library
Abstract Background An important fraction (>/~ 10%) of men with high‐risk, localized
prostate cancer and metastatic prostate cancer carry germline (heritable) pathogenic and …
prostate cancer and metastatic prostate cancer carry germline (heritable) pathogenic and …
Differences in Ovarian and Other Cancers Risks by Population and BRCA Mutation Location
M Sekine, K Nishino, T Enomoto - Genes, 2021 - mdpi.com
Hereditary breast and ovarian cancer is caused by a germline mutation in BRCA1 or BRCA2
genes. The frequency of germline BRCA1/2 gene mutation carriers and the ratio of germline …
genes. The frequency of germline BRCA1/2 gene mutation carriers and the ratio of germline …
An inherited NBN mutation is associated with poor prognosis prostate cancer
C Cybulski, D Wokołorczyk, W Kluźniak… - British journal of …, 2013 - nature.com
Background: To establish the contribution of eight founder alleles in three DNA damage
repair genes (BRCA1, CHEK2 and NBS1) to prostate cancer in Poland, and to measure the …
repair genes (BRCA1, CHEK2 and NBS1) to prostate cancer in Poland, and to measure the …
Germline DNA repair gene mutation landscape in Chinese prostate cancer patients
Genetic testing for prostate cancer (PCa) patients is in constant development. Specific
genetic alterations indicate personalized managing strategies, requiring clinicians to refer …
genetic alterations indicate personalized managing strategies, requiring clinicians to refer …
Genomic testing in patients with metastatic castration-resistant prostate cancer: a pragmatic guide for clinicians
AS Merseburger, N Waldron, MJ Ribal, A Heidenreich… - European Urology, 2021 - Elsevier
Context Genomic testing is becoming increasingly important in patients with advanced
prostate cancer (PC) and is being incorporated in clinical practice to guide treatment …
prostate cancer (PC) and is being incorporated in clinical practice to guide treatment …