According to Darwin's theory, endless evolution leads to a revolution. One such example is
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …

Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was
recently reported using genetically modified pigs and a clinically applicable drug treatment …

Although major advances in genomics have initiated an exciting new era of research, a lack
of information regarding cis-regulatory elements has limited the genetic improvement or …

The recent pig heart transplant in a patient at the University of Maryland Medical Center has
stimulated renewed interest in the xenotransplantation of organs from genetically …

Genetically engineered pigs are now available for xenotransplantation in which all three
known carbohydrate xenoantigens, against which humans have natural antibodies, have …

Germline editing, the process by which the genome of an individual is edited in such a way
that the change is heritable, has been applied to a wide variety of animals [DA Sorrell, AF …

The number of donated human organs and tissues for patients with terminal organ failure
falls far short of the need. Alternative sources, such as organs and tissues from animals, are …

Organ shortage is a major bottleneck in allotransplantation and causes many wait-listed
patients to die or become too sick for transplantation. Genetically engineered pigs have …

Introduction Cardiac xenotransplantation presents significant potential to the field of heart
failure by addressing the high demand for donor organs. The availability of xenograft hearts …

In transplantation, the ever-increasing number of an organ's demand and long-term graft
dysfunction constitute some of the major problems. Therefore, alternative solutions to …