DNA methylation in stress and depression: from biomarker to therapeutics

AJ Sales, FS Guimarães, SRL Joca - Acta Neuropsychiatrica, 2021 - cambridge.org
Epigenetic mechanisms such as DNA methylation (DNAm) have been associated with stress
responses and increased vulnerability to depression. Abnormal DNAm is observed in …

Stress across generations: DNA methylation as a potential mechanism underlying intergenerational effects of stress in both post-traumatic stress disorder and pre …

S Bhattacharya, A Fontaine, PE MacCallum… - Frontiers in Behavioral …, 2019 - frontiersin.org
Although most humans will experience some type of traumatic event in their lifetime only a
small set of individuals will go on to develop post-traumatic stress disorder (PTSD) …

Caregiver maltreatment causes altered neuronal DNA methylation in female rodents

J Blaze, TL Roth - Development and psychopathology, 2017 - cambridge.org
Negative experiences with a caregiver during infancy can result in long-term changes in
brain function and behavior, but underlying mechanisms are not well understood. It is our …

Hormones and human developmental plasticity

D Ponzi, MV Flinn, MP Muehlenbein… - Molecular and cellular …, 2020 - Elsevier
Natural selection favors the evolution of mechanisms that optimize the allocation of
resources and time among competing traits. Hormones mediate developmental plasticity …

[HTML][HTML] The epigenetics of animal personality

K van Oers, K van den Heuvel, B Sepers - Neuroscience & Biobehavioral …, 2023 - Elsevier
Animal personality, consistent individual differences in behaviour, is an important concept
for understanding how individuals vary in how they cope with environmental challenges. In …

Intrauterine exposure to maternal stress alters Bdnf IV DNA methylation and telomere length in the brain of adult rat offspring

J Blaze, A Asok, K Borrelli, C Tulbert, J Bollinger… - International Journal of …, 2017 - Elsevier
DNA methylation (addition of methyl groups to cytosines) and changes in telomere length
(TTAGGG repeats on the ends of chromosomes) are two molecular modifications that result …

Epigenetics and Early Life Stress: Experimental Brood Size Affects DNA Methylation in Great Tits (Parus major)

B Sepers, JAM Erven, F Gawehns, VN Laine… - Frontiers in Ecology …, 2021 - frontiersin.org
Early developmental conditions are known to have life-long effects on an individual's
behavior, physiology and fitness. In altricial birds, a majority of these conditions, such as the …

Tracking the path of predator recognition in a predator-naive population of the pond snail

A Batabyal, K Lukowiak - Behavioral Ecology, 2023 - academic.oup.com
Organisms evolve adaptive strategies to adjust to rapidly changing environmental stressors.
Predation pressure is one of the strongest selective forces and organisms respond to …

A short pre-conception bout of predation risk affects both children and grandchildren

S Bhattacharya, PE MacCallum, M Dayma… - Scientific Reports, 2023 - nature.com
Traumatic events that affect physiology and behavior in the current generation may also
impact future generations. We demonstrate that an ecologically realistic degree of predation …

Pharmacological manipulation of DNA methylation normalizes maternal behavior, DNA methylation, and gene expression in dams with a history of maltreatment

SM Keller, TS Doherty, TL Roth - Scientific reports, 2019 - nature.com
The quality of parental care received during development profoundly influences an
individual's phenotype, including that of maternal behavior. We previously found that female …