Effects of intranasal administration of oxytocin and vasopressin on social cognition and potential routes and mechanisms of action

S Yao, KM Kendrick - Pharmaceutics, 2022 - mdpi.com
Acute and chronic administration of intranasal oxytocin and vasopressin have been
extensively utilized in both animal models and human preclinical and clinical studies over …

Crosstalk between schizophrenia and metabolic syndrome: The role of oxytocinergic dysfunction

KK Goh, CYA Chen, TH Wu, CH Chen… - International journal of …, 2022 - mdpi.com
The high prevalence of metabolic syndrome in persons with schizophrenia has spurred
investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis …

Effects of multiple-dose intranasal oxytocin administration on social responsiveness in children with autism: a randomized, placebo-controlled trial

N Daniels, M Moerkerke, J Steyaert, A Bamps… - Molecular Autism, 2023 - Springer
Background Intranasal administration of oxytocin is increasingly explored as a new
approach to facilitate social development and reduce disability associated with a diagnosis …

Infrequent intranasal oxytocin followed by positive social interaction improves symptoms in autistic children: a pilot randomized clinical trial

J Le, L Zhang, W Zhao, S Zhu, C Lan, J Kou… - Psychotherapy and …, 2022 - karger.com
Introduction: There are currently no approved drug interventions for social behavior
dysfunction in autism spectrum disorder (ASD). Previous trials investigating effects of daily …

Oxytocin receptor single nucleotide polymorphism predicts atony-related postpartum hemorrhage

EN Erickson, KM Krol, AM Perkeybile… - BMC Pregnancy and …, 2022 - Springer
Background Postpartum hemorrhage remains a key contributor to overall maternal morbidity
in the United States. Current clinical assessment methods used to predict postpartum …

In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing

J Kou, C Lan, Y Zhang, Q Wang, F Zhou, Z Zhao… - Translational …, 2021 - nature.com
Intranasal oxytocin exerts wide-ranging effects on socioemotional behavior and is proposed
as a potential therapeutic intervention in psychiatric disorders. However, following intranasal …

Heterogeneity in response to repeated intranasal oxytocin in schizophrenia and autism spectrum disorders: A meta‐analysis of variance

D Martins, M Paduraru… - British Journal of …, 2022 - Wiley Online Library
Intranasal oxytocin (OT) has been suggested as a putative adjunctive treatment for patients
with schizophrenia and autism spectrum disorders (ASD). Here, we examine available …

Anxiolytic effects of chronic intranasal oxytocin on neural responses to threat are dose-frequency dependent

J Kou, Y Zhang, F Zhou, Z Gao, S Yao… - Psychotherapy and …, 2022 - karger.com
Introduction: Anxiety disorders are prevalent mental conditions characterized by
exaggerated anxious arousal and threat reactivity. Animal and human studies suggest an …

Intranasal vasopressin like oxytocin increases social attention by influencing top-down control, but additionally enhances bottom-up control

Q Zhuang, X Zheng, B Becker, W Lei, X Xu… - …, 2021 - Elsevier
The respective roles of the neuropeptides arginine vasopressin (AVP) and oxytocin (OXT) in
modulating social cognition and for therapeutic intervention in autism spectrum disorder …

Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men

M Coenjaerts, B Adrovic, I Trimborn, A Philipsen… - Scientific reports, 2023 - nature.com
Possible interactions of the neuropeptide oxytocin and the sex hormone estradiol may
contribute to previously observed sex-specific effects of oxytocin on resting-state functional …