The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

[HTML][HTML] Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation

CA Labarrere, GS Kassab - Frontiers in Nutrition, 2022 - frontiersin.org
Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

[HTML][HTML] Implication of COVID-19 on erythrocytes functionality: red blood cell biochemical implications and morpho-functional aspects

A Russo, E Tellone, D Barreca, S Ficarra… - International journal of …, 2022 - mdpi.com
Several diseases (such as diabetes, cancer, and neurodegenerative disorders) affect the
morpho-functional aspects of red blood cells, sometimes altering their normal metabolism. In …

[HTML][HTML] GlyNAC (glycine and N-acetylcysteine) supplementation in mice increases length of life by correcting glutathione deficiency, oxidative stress, mitochondrial …

P Kumar, OW Osahon, RV Sekhar - Nutrients, 2022 - mdpi.com
Determinants of length of life are not well understood, and therefore increasing lifespan is a
challenge. Cardinal theories of aging suggest that oxidative stress (OxS) and mitochondrial …

[HTML][HTML] Cellular compartmentalization, glutathione transport and its relevance in some pathologies

H Vázquez-Meza, MM Vilchis-Landeros… - Antioxidants, 2023 - mdpi.com
Reduced glutathione (GSH) is the most abundant non-protein endogenous thiol. It is a
ubiquitous molecule produced in most organs, but its synthesis is predominantly in the liver …

Sulfur compounds: From plants to humans and their role in chronic disease prevention

CR Hill, A Shafaei, L Balmer, JR Lewis… - Critical Reviews in …, 2023 - Taylor & Francis
Sulfur is essential for the health of plants and is an indispensable dietary component for
human health and disease prevention. Its incorporation into our food supply is heavily reliant …

[HTML][HTML] The role of cell death in SARS-CoV-2 infection

C Yuan, Z Ma, J Xie, W Li, L Su, G Zhang, J Xu… - … and Targeted Therapy, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), showing high
infectiousness, resulted in an ongoing pandemic termed coronavirus disease 2019 (COVID …

[HTML][HTML] Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease

CA Labarrere, GS Kassab - Frontiers in Microbiology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus
disease 19 (COVID-19) has numerous risk factors leading to severe disease with high …

[HTML][HTML] Green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG): a time for a new player in the treatment of respiratory diseases?

D Mokra, J Adamcakova, J Mokry - Antioxidants, 2022 - mdpi.com
(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a
wide variety of actions. EGCG acts as a strong antioxidant which effectively scavenges …

[HTML][HTML] Ferroptosis in COVID-19-related liver injury: A potential mechanism and therapeutic target

Y Chen, Y Xu, K Zhang, L Shen… - Frontiers in cellular and …, 2022 - frontiersin.org
The outbreak of COVID-19, which is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has spread worldwide and caused dramatic threaten of global …