Toll-like receptors in immunity and inflammatory diseases: Past, present, and future
K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …
cope with various pathogens present in the vicinity of environmental surroundings inhabited …
'From immunosenescence to immune modulation': a re-appraisal of the role of cytomegalovirus as major regulator of human immune function
P Moss - Medical microbiology and immunology, 2019 - Springer
In the year 2000, cytomegalovirus was identified as a risk factor for mortality in a seminal
study of octogenarian residents in Sweden. This finding triggered a wave of additional …
study of octogenarian residents in Sweden. This finding triggered a wave of additional …
The potential of toll-like receptors to modulate avian immune system: exploring the effects of genetic variants and phytonutrients
Toll-like receptors (TLRs) are pathogen recognition receptors, and primitive sources of
innate immune response that also play key roles in the defense mechanism against …
innate immune response that also play key roles in the defense mechanism against …
The toll-like receptor 4 polymorphism Asp299Gly is associated with an increased risk of ovarian cancer
KD Kania, D Haręża, JR Wilczyński, M Wilczyński… - Cells, 2022 - mdpi.com
Ovarian cancer (OC) is one of the most common cancers threatening women's lives around
the world. Epithelial ovarian tumors represent the most common ovarian neoplasms. Most …
the world. Epithelial ovarian tumors represent the most common ovarian neoplasms. Most …
Insights into the dynamic nature of the dsRNA-bound TLR3 complex
V Gosu, S Son, D Shin, KD Song - Scientific reports, 2019 - nature.com
Abstract Toll-like receptor 3 (TLR3), an endosomal receptor crucial for immune responses
upon viral invasion. The TLR3 ectodomain (ECD) is responsible for double-stranded RNA …
upon viral invasion. The TLR3 ectodomain (ECD) is responsible for double-stranded RNA …
Association between Zika virus microcephaly in newborns with the rs3775291 variant in toll-like receptor 3 and rs1799964 variant at tumor necrosis factor-α gene
CNO Santos, DR Ribeiro… - The Journal of …, 2019 - academic.oup.com
Congenital Zika syndrome (CZS) is a cluster of malformation, and the mechanisms that lead
it are still unclear. Using hypothesis-driven candidate genes and their function in viral …
it are still unclear. Using hypothesis-driven candidate genes and their function in viral …
Why does SARS-CoV-2 hit in different ways? Host genetic factors can influence the acquisition or the course of COVID-19
The identification of high-risk factors for the infection by SARS-CoV-2 and the negative
outcome of COVID-19 is crucial. The genetic background of the host might account for …
outcome of COVID-19 is crucial. The genetic background of the host might account for …
Genetic polymorphisms in TLR3, IL10 and CD209 influence the risk of BK polyomavirus infection after kidney transplantation
N Redondo, I Rodríguez-Goncer, P Parra… - Scientific Reports, 2022 - nature.com
Genetic determinants of BK polyomavirus infection after kidney transplantation remain
poorly investigated. We assessed the potential impact of 13 different single nucleotide …
poorly investigated. We assessed the potential impact of 13 different single nucleotide …
Polygenic innate immunity score to predict the risk of Cytomegalovirus infection in CMV D+/R-transplant recipients. A prospective multicenter cohort study
M Bodro, C Cervera, L Linares, B Suárez… - Frontiers in …, 2022 - frontiersin.org
Several genetic polymorphisms of the innate immune system have been described to
increase the risk of cytomegalovirus (CMV) infection in transplant patients. The aim of this …
increase the risk of cytomegalovirus (CMV) infection in transplant patients. The aim of this …
The TLR3 L412F polymorphism prevents TLR3-mediated tumor cell death induction in pediatric sarcomas
J Bisaccia, S Meyer, A Bertrand-Chapel… - Cell Death …, 2023 - nature.com
Abstract Toll-like receptor 3 (TLR3) is a pattern recognition receptor mainly known for its role
in innate immune response to infection. Indeed, binding of double-stranded RNA (dsRNA) to …
in innate immune response to infection. Indeed, binding of double-stranded RNA (dsRNA) to …