Mitochondria are multifaceted organelles with key roles in anabolic and catabolic
metabolism, bioenergetics, cellular signalling and nutrient sensing, and programmed cell …

Crosslinking mass spectrometry (crosslinking-MS) is a versatile tool providing structural
insights into protein conformation and protein-protein interactions. Its medium-resolution …

The mammalian respiratory chain complexes I, III 2, and IV (CI, CIII 2, and CIV) are critical for
cellular bioenergetics and form a stable assembly, the respirasome (CI-CIII 2-CIV), that is …

Current methods for intracellular protein analysis mostly require the separation of specific
organelles or changes to the intracellular environment. However, the functions of proteins …

Protein-protein interactions govern most cellular pathways and processes, and multiple
technologies have emerged to systematically map them. Assessing the error of interaction …

Cross-linking mass spectrometry has become an established technology to provide
structural information on the topology and dynamics of protein complexes. Readily …

Crosslinking mass spectrometry has become a core technology in structural biology and is
expanding its reach towards systems biology. Its appeal lies in a rapid workflow, high …

The majority of the pyruvate inside plant mitochondria is either transported into the matrix
from the cytosol via the mitochondria pyruvate carrier (MPC) or synthesized in the matrix by …

Combining mass spectrometry–based chemical cross-linking and complexome profiling, we
analyzed the interactome of heart mitochondria. We focused on complexes of oxidative …

Structural plasticity and dynamic protein–protein interactions are critical determinants of
protein function within living systems. Quantitative chemical cross-linking with mass …