Although usually benign, anterior pituitary tumours occasionally exhibit aggressive
behaviour, with invasion of surrounding tissues, rapid growth, resistance to conventional …

Adenohypophyseal tumors, which were recently renamed pituitary neuroendocrine tumors
(PitNET), are mostly benign, but may present various behaviors: invasive,“aggressive” and …

Prevalence and incidence of prolactinomas are approximately 50 per 100,000 and 3–5 new
cases/100,000/year. The pathophysiological mechanism of hyperprolactinemia-induced …

Prolactinomas are the most frequent pituitary adenomas. Prolactinoma may occur in different
clinical settings and always require an individually tailored approach. This is the reason why …

Prolactinomas are the most frequent pituitary adenomas. Prolactinoma may occur in different
clinical settings and always require an individually tailored approach. This is the reason why …

Replication stress (RS) induced by DNA damage plays a significant role in conferring the
anticancer effects of radiotherapy and is tightly associated with radioresistance of cancer …

Objective A somatic mutational hotspot in the SF3B1 gene was reported in lactotroph
tumours. The aim of our study was to examine the prevalence of driver SF3B1 variants in a …

Radiotherapy, conventional or radiosurgery, has been used to control prolactin secretion
and tumour growth in prolactinomas both as part of multimodal therapy or rarely as primary …

Abstract Purpose Pituitary neuroendocrine tumors (PitNETs) are frequent intracranial
neoplasms that present heterogenic characteristics. Little is known about the immune cell …

A small subset of lactotroph adenomas is resistant to dopamine agonists (DA) and can also
demonstrate aggressive or even malignant behavior. The implicated mechanisms are not …