The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

We aimed to investigate whether increased consumption of fructose is linked to the
increased prevalence of fatty liver. The prevalence of nonalcoholic steatohepatitis (NASH) is …

Purpose Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently
used drugs, and this widespread use is complicated by safety issues. Method A Literature …

Although frequently examined as a target organ for non-endocrine toxicity, histopathological
evaluation of the liver is becoming a routine component of endocrine disruption studies that …

Curcumin, the natural yellow‐colored active principle, also called turmeric yellow, extracted
from the perennial herb Curcuma longa L., has potent biological and pharmacological …

Primary human hepatocytes (PHHs) are a limited resource for drug screening, their quality
for in vitro use can vary considerably across different lots, and a lack of available donor …

Consumer and environmental safety decisions are based on exposure and hazard data,
interpreted using risk assessment approaches. The adverse outcome pathway (AOP) …

Because drug-induced liver injury (DILI) remains a major reason for late-stage drug attrition,
predictive assays are needed that can be deployed throughout the drug discovery process …

There are numerous physiologic and biochemical changes in menopause that can affect the
function of the liver and mediate the development of liver disease. Menopause represents a …

The inner bark of cinnamon (Cinnamomum zeylanicum L.) is commonly used as a spice and
has also been widely employed in the treatment and prevention of disease. The aim of the …