Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
Updates on mouse models of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …
States (US). Animal models, specifically mouse models have been developed to better …
Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease–associated genes
A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …
contribution of each variant to disease mechanism remains largely unknown. We have …
Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β
We show that a natural behavior, exploration of a novel environment, causes DNA double-
strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple …
strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple …
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
Many potential treatments for Alzheimer's disease target amyloid-β peptides (Aβ), which are
widely presumed to cause the disease. The microtubule-associated protein tau is also …
widely presumed to cause the disease. The microtubule-associated protein tau is also …
[HTML][HTML] Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
Neural network dysfunction may play an important role in Alzheimer's disease (AD).
Neuronal circuits vulnerable to AD are also affected in human amyloid precursor protein …
Neuronal circuits vulnerable to AD are also affected in human amyloid precursor protein …
AMPAR removal underlies Aβ-induced synaptic depression and dendritic spine loss
Beta amyloid (Aβ), a peptide generated from the amyloid precursor protein (APP) by
neurons, is widely believed to underlie the pathophysiology of Alzheimer's disease. Recent …
neurons, is widely believed to underlie the pathophysiology of Alzheimer's disease. Recent …
Amyloid β-induced neuronal hyperexcitability triggers progressive epilepsy
R Minkeviciene, S Rheims, MB Dobszay… - Journal of …, 2009 - Soc Neuroscience
Alzheimer's disease is associated with an increased risk of unprovoked seizures. However,
the underlying mechanisms of seizure induction remain elusive. Here, we performed video …
the underlying mechanisms of seizure induction remain elusive. Here, we performed video …
Epilepsy and cognitive impairments in Alzheimer disease
Alzheimer disease (AD) is associated with cognitive decline and increased incidence of
seizures. Seizure activity in AD has been widely interpreted as a secondary process …
seizures. Seizure activity in AD has been widely interpreted as a secondary process …
[图书][B] What's wrong with my mouse?: behavioral phenotyping of transgenic and knockout mice
JN Crawley - 2007 - books.google.com
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …