Chordoma: current status, problems, and future directions
MF Wedekind, BC Widemann, G Cote - Current Problems in Cancer, 2021 - Elsevier
Chordoma is a rare tumor that occurs along the axial spine in pediatrics and adults, with an
incidence of approximately 350 cases per year in the United States. While typically …
incidence of approximately 350 cases per year in the United States. While typically …
Chordoma: a comprehensive systematic review of clinical trials
S Chen, R Ulloa, J Soffer, RJ Alcazar-Felix… - Cancers, 2023 - mdpi.com
Simple Summary Surgery is the primary treatment for chordoma. However, residual or
recurrent chordoma presents a significant problem for clinicians. The aim of this work is to …
recurrent chordoma presents a significant problem for clinicians. The aim of this work is to …
MicroRNA-608 and microRNA-34a regulate chordoma malignancy by targeting EGFR, Bcl-xL and MET
Y Zhang, D Schiff, D Park, R Abounader - PloS one, 2014 - journals.plos.org
Chordomas are rare malignant tumors that originate from the notochord remnants and occur
in the skull base, spine and sacrum. Due to a very limited understanding of the molecular …
in the skull base, spine and sacrum. Due to a very limited understanding of the molecular …
Novel targeted therapies in chordoma: an update
S Di Maio, S Yip, GA Al Zhrani, FE Alotaibi… - … and clinical risk …, 2015 - Taylor & Francis
Chordomas are rare, locally aggressive skull base neoplasms known for local recurrence
and not-infrequent treatment failure. Current evidence supports the role of maximal safe …
and not-infrequent treatment failure. Current evidence supports the role of maximal safe …
Emerging therapeutic targets in chordomas: a review of the literature in the genomic era
CM Gill, M Fowkes, RK Shrivastava - Neurosurgery, 2020 - journals.lww.com
Chordomas are rare primary malignant tumors of the bones that occur along the skull base,
spine, and sacrum. Long-term survival and neurological outcome continue to be challenging …
spine, and sacrum. Long-term survival and neurological outcome continue to be challenging …
The molecular aspects of chordoma
S Gulluoglu, O Turksoy, A Kuskucu, U Ture… - Neurosurgical …, 2016 - Springer
Chordomas are one of the rarest bone tumors, and they originate from remnants of
embryonic notochord along the spine, more frequently at the skull base and sacrum …
embryonic notochord along the spine, more frequently at the skull base and sacrum …
Expression of PDGFR-α, EGFR and c-MET in spinal chordoma: a series of 52 patients
R Akhavan-Sigari, MR Gaab, V Rohde… - Anticancer …, 2014 - ar.iiarjournals.org
Aim: To investigate the expression of platelet-derived growth factor (PDGF) receptor-A
(PDGFRα), epidermal growth factor receptor (EGFR) and c-Met in spinal chordoma. To the …
(PDGFRα), epidermal growth factor receptor (EGFR) and c-Met in spinal chordoma. To the …
Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review
SG Launay, B Chetaille, F Medina, D Perrot… - BMC cancer, 2011 - Springer
Background Chordomas are very rare low-grade malignant bone tumors that arise from the
embryonic rests of the notochord. They are characterized by slow growth and long history …
embryonic rests of the notochord. They are characterized by slow growth and long history …
Erlotinib inhibits growth of a patient-derived chordoma xenograft
Chordomas are rare primary bone tumors that occur along the neuraxis. Primary treatment is
surgery, often followed by radiotherapy. Treatment options for patients with recurrence are …
surgery, often followed by radiotherapy. Treatment options for patients with recurrence are …
A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12
Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord,
with its origin in the bones of the axial skeleton. Surgical resection is the standard treatment …
with its origin in the bones of the axial skeleton. Surgical resection is the standard treatment …