Epigenetic treatment has been approved by regulatory agencies for haematological
malignancies. The success observed in cutaneous lymphomas represents a proof of …

Gene expression in cells is determined by the epigenetic state of chromatin. Therefore, the
study of epigenetic changes is very important to understand the regulatory mechanism of …

Strand asymmetry in the distribution of guanines and cytosines, measured by GC skew,
predisposes DNA sequences toward R-loop formation upon transcription. Previous work …

DNA methylation is an epigenetic mechanism for gene silencing engaged by DNA
methyltransferase (Dnmt)-catalyzed methyl group transfer to cytosine residues in gene …

DNMT3A mutations are associated with poor prognosis in acute myeloid leukemia (AML),
but the stability of this mutation during the clinical course remains unclear. In the present …

Epigenetic modification can mediate environmental influences on gene expression and can
modulate the disease risk associated with genetic variation. Epigenetic analysis therefore …

Mechanisms regulating myofibroblastic differentiation of fibroblasts within fibroblastic foci in
idiopathic pulmonary fibrosis (IPF) remain unclear. Epigenetic processes, including DNA …

Cytosine methylation is an epigenetic modification of DNA catalyzed by DNA
methyltransferases. Cytosine methylation of mitochondrial DNA (mtDNA) is believed to have …

Breast carcinogenesis involves genetic and epigenetic alterations that cause aberrant gene
function. Recent progress in the knowledge of epigenomics has had a profound impact on …

Amyotrophic lateral sclerosis (ALS) is a fatal disease. Skeletal muscles and motor neurons
(MNs) degenerate. ALS is a complex disease involving many genes in multiple tissues, the …