Epigenetic treatment of solid tumours: a review of clinical trials
C Nervi, E De Marinis, G Codacci-Pisanelli - Clinical epigenetics, 2015 - Springer
Epigenetic treatment has been approved by regulatory agencies for haematological
malignancies. The success observed in cutaneous lymphomas represents a proof of …
malignancies. The success observed in cutaneous lymphomas represents a proof of …
Effects of DNA methylation on gene expression and phenotypic traits in cattle: A review
J Zhang, H Sheng, C Hu, F Li, B Cai, Y Ma… - International Journal of …, 2023 - mdpi.com
Gene expression in cells is determined by the epigenetic state of chromatin. Therefore, the
study of epigenetic changes is very important to understand the regulatory mechanism of …
study of epigenetic changes is very important to understand the regulatory mechanism of …
GC skew at the 5′ and 3′ ends of human genes links R-loop formation to epigenetic regulation and transcription termination
Strand asymmetry in the distribution of guanines and cytosines, measured by GC skew,
predisposes DNA sequences toward R-loop formation upon transcription. Previous work …
predisposes DNA sequences toward R-loop formation upon transcription. Previous work …
Epigenetic regulation of motor neuron cell death through DNA methylation
BA Chestnut, Q Chang, A Price, C Lesuisse… - Journal of …, 2011 - Soc Neuroscience
DNA methylation is an epigenetic mechanism for gene silencing engaged by DNA
methyltransferase (Dnmt)-catalyzed methyl group transfer to cytosine residues in gene …
methyltransferase (Dnmt)-catalyzed methyl group transfer to cytosine residues in gene …
DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications
HA Hou, YY Kuo, CY Liu, WC Chou… - Blood, The Journal …, 2012 - ashpublications.org
DNMT3A mutations are associated with poor prognosis in acute myeloid leukemia (AML),
but the stability of this mutation during the clinical course remains unclear. In the present …
but the stability of this mutation during the clinical course remains unclear. In the present …
Prospects for epigenetic epidemiology
Epigenetic modification can mediate environmental influences on gene expression and can
modulate the disease risk associated with genetic variation. Epigenetic analysis therefore …
modulate the disease risk associated with genetic variation. Epigenetic analysis therefore …
Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis
Mechanisms regulating myofibroblastic differentiation of fibroblasts within fibroblastic foci in
idiopathic pulmonary fibrosis (IPF) remain unclear. Epigenetic processes, including DNA …
idiopathic pulmonary fibrosis (IPF) remain unclear. Epigenetic processes, including DNA …
Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS
M Wong, B Gertz, BA Chestnut… - Frontiers in cellular …, 2013 - frontiersin.org
Cytosine methylation is an epigenetic modification of DNA catalyzed by DNA
methyltransferases. Cytosine methylation of mitochondrial DNA (mtDNA) is believed to have …
methyltransferases. Cytosine methylation of mitochondrial DNA (mtDNA) is believed to have …
Epigenomics and breast cancer
PK Lo, S Sukumar - Pharmacogenomics, 2008 - Taylor & Francis
Breast carcinogenesis involves genetic and epigenetic alterations that cause aberrant gene
function. Recent progress in the knowledge of epigenomics has had a profound impact on …
function. Recent progress in the knowledge of epigenomics has had a profound impact on …
Aberrant DNA and RNA methylation occur in spinal cord and skeletal muscle of human SOD1 mouse models of ALS and in human ALS: targeting DNA methylation is …
LJ Martin, DA Adams, MV Niedzwiecki, M Wong - Cells, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal disease. Skeletal muscles and motor neurons
(MNs) degenerate. ALS is a complex disease involving many genes in multiple tissues, the …
(MNs) degenerate. ALS is a complex disease involving many genes in multiple tissues, the …