[HTML][HTML] Emerging therapies for glioblastoma: current state and future directions

L Rong, N Li, Z Zhang - Journal of Experimental & Clinical Cancer …, 2022 - Springer
Glioblastoma (GBM) is the most common high-grade primary malignant brain tumor with an
extremely poor prognosis. Given the poor survival with currently approved treatments for …

Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance

S Salunkhe, M Basak, D Chitkara, A Mittal - Journal of Controlled …, 2020 - Elsevier
Exosomes are natural nanovesicles excreted by many cells for intercellular communication
and for transfer of materials including proteins, nucleic acids and even synthetic therapeutic …

Tumor microenvironment in glioblastoma: Current and emerging concepts

P Sharma, A Aaroe, J Liang… - Neuro-Oncology …, 2023 - academic.oup.com
Glioblastoma (GBM) tumor microenvironment (TME) is a highly heterogeneous and complex
system, which in addition to cancer cells, consists of various resident brain and immune cells …

Nanomedicine for brain cancer

S Quader, K Kataoka, H Cabral - Advanced Drug Delivery Reviews, 2022 - Elsevier
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

[HTML][HTML] Current and future trends on diagnosis and prognosis of glioblastoma: from molecular biology to proteomics

AS Silantyev, L Falzone, M Libra, OI Gurina… - Cells, 2019 - mdpi.com
Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous
system. Due to the absence of effective pharmacological and surgical treatments, the …

Mouse models of glioblastoma for the evaluation of novel therapeutic strategies

AF Haddad, JS Young, D Amara… - Neuro-oncology …, 2021 - academic.oup.com
Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15
months despite an aggressive standard of care that includes surgery, chemotherapy, and …

Genomic and phenotypic characterization of a broad panel of patient-derived xenografts reflects the diversity of glioblastoma

RA Vaubel, S Tian, D Remonde, MA Schroeder… - Clinical Cancer …, 2020 - AACR
Purpose: Glioblastoma is the most frequent and lethal primary brain tumor. Development of
novel therapies relies on the availability of relevant preclinical models. We have established …

Drug delivery challenges and future of chemotherapeutic nanomedicine for glioblastoma treatment

LP Ganipineni, F Danhier, V Préat - Journal of controlled release, 2018 - Elsevier
Glioblastoma (GBM) is one of the most aggressive and deadliest central nervous system
tumors, and the current standard treatment is surgery followed by radiotherapy with …

Dissecting and rebuilding the glioblastoma microenvironment with engineered materials

KJ Wolf, J Chen, JD Coombes, MK Aghi… - Nature Reviews …, 2019 - nature.com
Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer.
Several decades of research have provided great insight into GBM progression; however …

Rationally designed drug delivery systems for the local treatment of resected glioblastoma

C Bastiancich, A Malfanti, V Préat, R Rahman - Advanced drug delivery …, 2021 - Elsevier
Glioblastoma (GBM) is a particularly aggressive brain cancer associated with high
recurrence and poor prognosis. The standard of care, surgical resection followed by …