Mediation analysis in epidemiology: methods, interpretation and bias

L Richiardi, R Bellocco, D Zugna - International journal of …, 2013 - academic.oup.com
In epidemiological studies it is often necessary to disentangle the pathways that link an
exposure to an outcome. Typically the aim is to identify the total effect of the exposure on the …

[HTML][HTML] The limitations of large-scale volunteer databases to address inequalities and global challenges in health and aging

C Brayne, TE Moffitt - Nature Aging, 2022 - nature.com
Large-scale volunteer databanks (LSVD) have emerged from the recognized value of
cohorts, attracting substantial funding and promising great scientific value. A major focus is …

Genetic analyses identify widespread sex-differential participation bias

N Pirastu, M Cordioli, P Nandakumar, G Mignogna… - Nature Genetics, 2021 - nature.com
Genetic association results are often interpreted with the assumption that study participation
does not affect downstream analyses. Understanding the genetic basis of participation bias …

Exploring the association of genetic factors with participation in the Avon Longitudinal Study of Parents and Children

AE Taylor, HJ Jones, H Sallis, J Euesden… - International journal …, 2018 - academic.oup.com
Background It is often assumed that selection (including participation and dropout) does not
represent an important source of bias in genetic studies. However, there is little evidence to …

[HTML][HTML] The association between frailty and severe disease among COVID-19 patients aged over 60 years in China: a prospective cohort study

Y Ma, L Hou, X Yang, Z Huang, X Yang, N Zhao, M He… - BMC medicine, 2020 - Springer
Background The coronavirus disease 2019 (COVID-19) has been a pandemic worldwide.
Old age and underlying illnesses are associated with poor prognosis among COVID-19 …

Loss to follow-up in cohort studies: bias in estimates of socioeconomic inequalities

LD Howe, K Tilling, B Galobardes, DA Lawlor - Epidemiology, 2013 - journals.lww.com
Background: Although cohort members tend to be healthy and affluent compared with the
whole population, some studies indicate this does not bias certain exposure-outcome …

Commentary: Representativeness is usually not necessary and often should be avoided

L Richiardi, C Pizzi, N Pearce - International journal of …, 2013 - academic.oup.com
We agree with Rothman and colleagues that scientific inference in epidemiology does not
require representativeness of the general population or target population in order to be …

Who and what is a “population”? Historical debates, current controversies, and implications for understanding “population health” and rectifying health inequities

N Krieger - The Milbank Quarterly, 2012 - Wiley Online Library
Context: The idea of “population” is core to the population sciences but is rarely defined
except in statistical terms. Yet who and what defines and makes a population has everything …

Understanding the role of hyperdiploidy in myeloma prognosis: which trisomies really matter?

ML Chretien, J Corre… - Blood, The Journal …, 2015 - ashpublications.org
The prognosis of multiple myeloma is mainly dependent upon chromosomal changes. The 2
major abnormalities driving poor outcome are del (17p) and t (4; 14). However, the outcome …

Screen time is associated with adiposity and insulin resistance in children

CM Nightingale, AR Rudnicka, AS Donin… - Archives of disease in …, 2017 - adc.bmj.com
Background Higher screen time is associated with type 2 diabetes (T2D) risk in adults, but
the association with T2D risk markers in children is unclear. We examined associations …