Exudative age-related macular degeneration (AMD) is characterized by molecular
mechanisms responsible for the initiation of choroidal neovascularization (CNV) …

Cartilage mineralization is a tightly controlled process, imperative for skeletal growth and
fracture repair. However, in osteoarthritis (OA), cartilage mineralization may impact the joint …

Aims Cyclophosphamide is an alkylating agent with vast arrays of therapeutic activity.
Currently, its medical use is limited due to its numerous adverse events, including …

Objective To investigate the differences in gene expression profiles of adult articular
cartilage from patients with Kashin‐Beck disease (KBD) versus those with primary knee …

Fibrosis is characterized by fibroblast proliferation and fibroblast differentiation into
myofibroblasts, which generate a relaxation-free contraction mechanism associated with …

Reduced SIRT1 activity and levels during osteoarthritis (OA) promote gradual loss of
cartilage. Loss of cartilage matrix is accompanied by an increase in matrix metalloproteinase …

T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are downstream
effectors of Wnt/β-catenin signaling, which has been implicated in the development and …

Endothelial cells (ECs) form the lining of lymph and blood vessels. Changes in tissue
requirements or wounds may cause ECs to behave as tip or stalk cells. Alternatively, they …

Intervertebral disc degeneration (IVDD) is an age-related degenerative disease that is the
main cause of low back pain. It seriously affects the quality of life of patients and places a …

Congenital anomalies of the kidney and urinary tract (CAKUT) affect about 1 in 500 births
and are a major cause of morbidity in infants. Duplex collecting systems rank among the …