Immune checkpoint inhibition targeting T cells has shown tremendous promise in the
treatment of many cancer types and are now standard therapies for patients. While standard …

Systemic sclerosis (SSc) is a chronic disease characterized by microvasculopathy,
autoantibodies (autoAbs), and fibrosis. The pathogenesis of the disease is incompletely …

Objective It is unclear why activated platelets and platelet‐derived microparticles (MPs)
accumulate in the blood of patients with systemic sclerosis (SSc). This study was undertaken …

Rationale: Data on the molecular mechanisms that regulate platelet–pulmonary endothelial
adhesion under conditions of hypoxia are lacking, but may have important therapeutic …

Abstract Background aims CD4+ CD25+ CD127 lo regulatory T cells (Tregs) are responsible
for maintaining immune homeostasis. Tregs can be rendered defective and deficient as a …

Cerebral ischemic injury is an important factor affecting the prognosis of acute ischemic
stroke (AIS). Neuronal apoptosis and the change in microglial phenotype have been …

There is an unmet need for new therapeutic strategies that target alternative pathways to
improve the prognosis of patients with pulmonary arterial hypertension (PAH). As immunity …

Background and Purpose Interstitial lung disease (ILD) is the main cause of mortality in
systemic sclerosis (SSc), and current therapies available are of low efficacy or high toxicity …

BACKGROUND Acute pancreatitis (AP) is rapid-onset pancreatic inflammation that causes
local and systemic inflammatory response syndrome (SIRS) with high morbidity and …

PSGL-1 is expressed in all plasma cells, but only in a small percentage of circulating B cells.
Patients with systemic sclerosis (SSc) show reduced expression of PSGL-1 in B cells and …