Paclitaxel: application in modern oncology and nanomedicine‐based cancer therapy

J Sharifi-Rad, C Quispe, JK Patra… - Oxidative medicine …, 2021 - Wiley Online Library
Paclitaxel is a broad‐spectrum anticancer compound, which was derived mainly from a
medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a …

[HTML][HTML] Ricin: An ancient story for a timeless plant toxin

L Polito, M Bortolotti, MG Battelli, G Calafato… - Toxins, 2019 - mdpi.com
The castor plant (Ricinus communis L.) has been known since time immemorial in traditional
medicine in the pharmacopeia of Mediterranean and eastern ancient cultures. Moreover, it is …

Tutorial on monoclonal antibody pharmacokinetics and its considerations in early development

M Ovacik, K Lin - Clinical and translational science, 2018 - Wiley Online Library
The tutorial introduces the readers to the fundamentals of antibody pharmacokinetics (PK) in
the context of drug development. Topics covered include an overview of antibody …

[HTML][HTML] Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

M Bortolotti, D Mercatelli, L Polito - Frontiers in pharmacology, 2019 - frontiersin.org
Momordica charantia, commonly called bitter melon, is a plant belonging to Cucurbitaceae
family known for centuries for its pharmacological activities, and nutritional properties. Due …

[HTML][HTML] Ribosome-inactivating proteins from plants: A historical overview

A Bolognesi, M Bortolotti, S Maiello, MG Battelli… - Molecules, 2016 - mdpi.com
This review provides a historical overview of the research on plant ribosome-inactivating
proteins (RIPs), starting from the first studies at the end of eighteenth century involving the …

Effect of melatonin foliar sprays on morphophysiological attributes, fruit yield and quality of Momordica charantia L. under salinity stress

M Sheikhalipour, G Gohari, B Esmaielpour… - Plant Physiology and …, 2023 - Elsevier
Soil salinity is one of the increasing problems in agricultural fields in many parts of the world,
adversely affecting the performance and health of the plants. As a pleiotropic signal and …

[HTML][HTML] Intracellular transport and cytotoxicity of the protein toxin ricin

N Sowa-Rogozińska, H Sominka… - Toxins, 2019 - mdpi.com
Ricin can be isolated from the seeds of the castor bean plant (Ricinus communis). It belongs
to the ribosome-inactivating protein (RIP) family of toxins classified as a bio-threat agent due …

[HTML][HTML] Effect of Acute and Chronic Oral l-Carnitine Supplementation on Exercise Performance Based on the Exercise Intensity: A Systematic Review

J Mielgo-Ayuso, L Pietrantonio, A Viribay… - Nutrients, 2021 - mdpi.com
l-Carnitine (lC) and any of its forms (glycine-propionyl l-Carnitine (GPL-C) or l-Carnitine l-
tartrate (l-CLT)) has been frequently recommended as a supplement to improve sports …

Immunomodulatory effects and associated mechanisms of Momordica charantia and its phytochemicals

S Wang, Q Liu, T Zeng, J Zhan, H Zhao, CT Ho… - Food & Function, 2022 - pubs.rsc.org
Momordica charantia L.(M. charantia), which is a member of the Cucurbitaceae family and
widely distributed in tropical and subtropical regions, has been consumed as a vegetable …

[HTML][HTML] Glycosylated triterpenoids as endosomal escape enhancers in targeted tumor therapies

H Fuchs, N Niesler, A Trautner, S Sama, G Jerz… - Biomedicines, 2017 - mdpi.com
Protein-based targeted toxins play an increasingly important role in targeted tumor
therapies. In spite of their high intrinsic toxicity, their efficacy in animal models is low. A major …