The extracellular matrix (ECM) is a complex network of extracellular-secreted
macromolecules, such as collagen, enzymes and glycoproteins, whose main functions deal …

Abstract Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for
instance in the genesis of caveolae. Nonetheless, it is also present in many intracellular …

Lung adenocarcinoma (LUAD) is the most common histological form of lung cancer that is
clinically diagnosed. The aim of this study is to explore the novel genes associated with …

The existence of a tight relationship between inflammation and epigenetics that in primary
breast tumor cells can lead to tumor progression and the formation of bone metastases was …

Simple Summary Caveolin-1 (CAV1) is a membrane protein that has been attributed a dual
role in cancer, acting at early stages as a tumor suppressor and in later stages of the …

Lung adenocarcinoma (LUAD) accounts for a frequently seen non-small cell lung cancer
(NSCLC) histological subtype, and it is associated with dismal prognostic outcome …

Background Topoisomerase inhibitors (TI) can inhibit cell proliferation by preventing DNA
replication, stimulating DNA damage and inducing cell cycle arrest. Although these agents …

Simple Summary Cell membranes contain small invaginations called caveolae. They are a
specialized lipid domain and orchestrate cellular signaling events, mechanoprotection, and …

Abstract Caveolin-1 (CAV1) enhanced migration, invasion, and metastasis of cancer cells is
inhibited by co-expression of the glycoprotein E-cadherin. Although the two proteins form a …

Metastasis is the leading cause of cancer-related deaths, making the development of novel,
more effective therapies imperative to alleviate patient suffering. Metabolic switching is a …