The tumour microenvironment (TME) constitutes the area surrounding the tumour during its
development and has been demonstrated to play roles in cancer-related diseases through …

The role of stromal cells and the tumour microenvironment in general in modulating tumour
sensitivity is increasingly becoming a key consideration for the development of active …

Stem cells have emerged as a key element of regenerative medicine therapies due to their
inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous …

Background High invasion and metastasis are the primary factors causing poor prognosis of
patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms …

Triple negative breast cancer (TNBC) is a heterogeneous disease at the molecular,
pathologic and clinical levels. To stratify TNBCs, we determined microRNA (miRNA) …

It has been difficult to identify the molecular features central to the pathogenesis of
osteosarcoma owing to a lack of understanding of the cell or origin, the absence of …

Despite successful primary tumor treatment, the development of pulmonary metastasis
continues to be the most common cause of mortality in patients with osteosarcoma. A …

What has been will be again, what has been done will be done again; there is nothing new
under the sun (Ecclesiastes 1: 9) Stephen Paget was the conceptual father of the role played …

We examined cancer‐associated fibroblasts (CAFs) and a panel of immunohistochemical
markers of epithelial‐mesenchymal transition (EMT) in 19 pair‐matched oral tongue …

Individualizing cancer therapy for molecular targeted inhibitors requires a new class of
molecular profiling technology that can map the functional state of the cancer cell signal …