Endothelial to mesenchymal transition in health and disease
Y Xu, JC Kovacic - Annual Review of Physiology, 2023 - annualreviews.org
The endothelium is one of the largest organ systems in the body, and data continue to
emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and …
emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and …
New developments in the biology of fibroblast growth factors
DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies
H Christou, RA Khalil - American Journal of Physiology …, 2022 - journals.physiology.org
Pulmonary hypertension (PH) is a serious disease characterized by various degrees of
pulmonary vasoconstriction and progressive fibroproliferative remodeling and inflammation …
pulmonary vasoconstriction and progressive fibroproliferative remodeling and inflammation …
Decreased left heart flow in fetal lambs causes left heart hypoplasia and pro-fibrotic tissue remodeling
MS Reuter, DJ Sokolowski, J Javier Diaz-Mejia… - Communications …, 2023 - nature.com
Low blood flow through the fetal left heart is often conjectured as an etiology for hypoplastic
left heart syndrome (HLHS). To investigate if a decrease in left heart flow results in growth …
left heart syndrome (HLHS). To investigate if a decrease in left heart flow results in growth …
The role of endothelial-to-mesenchymal transition in cardiovascular disease
Endothelial-to-mesenchymal transition (EndoMT) is the process of endothelial cells
progressively losing endothelial-specific markers and gaining mesenchymal phenotypes. In …
progressively losing endothelial-specific markers and gaining mesenchymal phenotypes. In …
[HTML][HTML] The driving mechanism and targeting value of mimicry between vascular endothelial cells and tumor cells in tumor progression
X Ma, Z Geng, S Wang, Z Yu, T Liu, S Guan… - Biomedicine & …, 2023 - Elsevier
The difficulty and poor prognosis of malignant tumor have always been a difficult problem to
be solved. The internal components of solid tumor are complex, including tumor cells …
be solved. The internal components of solid tumor are complex, including tumor cells …
Endothelial to mesenchymal transition: at the axis of cardiovascular health and disease
Endothelial cells (ECs) line the luminal surface of blood vessels and play a major role in
vascular (patho)-physiology by acting as a barrier, sensing circulating factors and …
vascular (patho)-physiology by acting as a barrier, sensing circulating factors and …
Characterization of a robust mouse model of heart failure with preserved ejection fraction
D Matsiukevich, A Kovacs, T Li… - American Journal …, 2023 - journals.physiology.org
Heart failure (HF) is a leading cause of morbidity and mortality particularly in older adults
and patients with multiple metabolic comorbidities. Heart failure with preserved ejection …
and patients with multiple metabolic comorbidities. Heart failure with preserved ejection …
The role of PRRC2B in cerebral vascular remodeling under acute hypoxia in mice
S Li, W Hu, S Gong, P Zhang, J Cheng… - Advanced …, 2023 - Wiley Online Library
High altitude exposure leads to various cognitive impairments. The cerebral vasculature
system plays an integral role in hypoxia‐induced cognitive defects by reducing oxygen and …
system plays an integral role in hypoxia‐induced cognitive defects by reducing oxygen and …
Endothelial-to-mesenchymal transition: advances and controversies
M Simons - Current Opinion in Physiology, 2023 - Elsevier
Endothelial-to-mesenchymal transition (EndMT) is a physiological process that is equally
important during development and under certain pathological conditions in adult tissues …
important during development and under certain pathological conditions in adult tissues …