Background & Aims Central neuromodulators (antidepressants, antipsychotics, and other
central nervous system− targeted medications) are increasingly used for treatment of …

Opioids were one of the earliest classes of medications used for pain across a variety of
conditions, but morbidity and mortality have been increasingly associated with their chronic …

Study Design. Retrospective, economic analysis. Objective. To study patient profile
associated with preoperative chronic opioid therapy (COT), and study COT as a risk factor …

Constipation affects 14% of the adult population globally, mainly women, and significantly
impacts on health‐related quality of life. The causes of constipation are mainly three: lifestyle …

Abstract Background Context As health-care transitions to value-based models, there has
been an increased focus on patient factors that can influence peri-and postoperative …

Results Certain conventional pain managing drugs do not effectively improve IBS symptoms,
including NSAIDs, acetaminophen, aspirin, and various narcotics. Anxiolytic and …

Evidence supports the use of opioids for treating acute pain. However, the evidence is
limited for the use of chronic opioid therapy for chronic pain. Furthermore, the risks of chronic …

New models of health care have emerged over the past decade. Accountable care
organizations and patient-centered medical homes are designed to improve the patient …

Background Postoperative urinary retention (POUR) is a relatively common complication
after total joint arthroplasty (TJA). Based on the findings of a randomized, prospective study …

Introduction: The benefits of opioid therapy must be balanced by any adverse effects. In
recent years, prescription opioids have been increasingly prescribed, but have also been …