The present experiments examined the effects of adolescent nicotine pre-exposure on the
rewarding and aversive effects of cocaine and on cocaine self-administration in adult male …

Animal models have been developed to study the reinforcing effects of drugs, including the
intravenous self-administration (IVSA) paradigm. The advantages of using an IVSA …

The pervasive and devastating nature of substance use disorders underlies the need for the
continued development of novel pharmacotherapies. We now know that glia play a much …

ABSTRACT Activation of sigma1 (σ1) receptors contributes to the behavioral and toxic
effects of (−)‐cocaine. We studied a key step, the ability of (−)‐cocaine to occupy σ1 …

Initial sensitivity to psychostimulants can predict subsequent use and abuse in humans.
Acute locomotor activation in response to psychostimulants is commonly used as an animal …

Abstract Rationale Caveolin-1 (CAV1) is a structural protein critical for spatial organization of
neuronal signaling molecules. Whether CAV1 is required for long-lasting neuronal plasticity …

Cocaine use disorders (CUD) are devastating for affected individuals and impose a
significant societal burden, but there are currently no FDA-approved therapies. The …

Rationale Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but
this relationship is not always observed in human studies. Moreover, studies examining the …

Behavioral sensitization has been widely studied in animal models and is theorized to reflect
neural modifications associated with human psychostimulant addiction. While the …

Women use methamphetamine more frequently than men and are more vulnerable to its
negative psychological effects. Rodent models have been an essential tool for evaluating …