Corneal transplantation is the most successful solid organ transplantation performed in
humans. The extraordinary success of orthotopic corneal allografts, in both humans and …

Biomarkers provide a powerful and dynamic approach to improve our understanding of the
mechanisms underlying ocular diseases with applications in diagnosis, disease modulation …

Single-cell analysis in living humans is essential for understanding disease mechanisms,
but it is impractical in non-regenerative organs, such as the eye and brain, because tissue …

Diabetic retinopathy (DR), a sight-threatening neurovasculopathy, is the leading cause of
irreversible blindness in the developed world. DR arises as the result of prolonged …

The renin-angiotensin system (RAS), that is known for its role in the regulation of blood
pressure as well as in fluid and electrolyte homeostasis, comprises dozens of angiotensin …

Extracellular tissue fluids are interesting biomatrices that have recently attracted scientists'
interest. Many significant biomarkers for localized external organ diseases have been …

Glaucoma is a group of diseases involving the optic nerve and associated structures, which
is characterized by progressive visual field loss and typical changes of the optic nerve head …

Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …

Age-related macular degeneration (AMD) describes the progressive degeneration of the
retinal pigment epithelium (RPE), retina, and choriocapillaris and is the leading cause of …

Extracellular Vesicles (EVs), membrane vesicles released by all cells, are emerging
mediators of cell-cell communication. By carrying biomolecules from tissues to biofluids, EVs …