[HTML][HTML] DNA methylation: Precise modulation of chromatin structure and dynamics
DNA methylation plays a vital role in epigenetic regulation in both plants and animals, and
typically occurs at the 5-carbon position of the cytosine pyrimidine ring within the CpG …
typically occurs at the 5-carbon position of the cytosine pyrimidine ring within the CpG …
CRISPR/dCas9-based systems: mechanisms and applications in plant sciences
RNA-guided genomic transcriptional regulation tools, namely clustered regularly
interspaced short palindromic repeats interference (CRISPRi) and CRISPR-mediated gene …
interspaced short palindromic repeats interference (CRISPRi) and CRISPR-mediated gene …
Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation
S Kaluscha, S Domcke, C Wirbelauer, MB Stadler… - Nature …, 2022 - nature.com
Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
Prediction of protein–ligand binding affinity from sequencing data with interpretable machine learning
Protein–ligand interactions are increasingly profiled at high throughput using affinity
selection and massively parallel sequencing. However, these assays do not provide the …
selection and massively parallel sequencing. However, these assays do not provide the …
Associations between DNA methylation and gene regulation depend on chromatin accessibility during transgenerational plasticity
Background Epigenetic processes are proposed to be a mechanism regulating gene
expression during phenotypic plasticity. However, environmentally induced changes in DNA …
expression during phenotypic plasticity. However, environmentally induced changes in DNA …
Epigenetic gene regulation in plants and its potential applications in crop improvement
H Zhang, JK Zhu - Nature Reviews Molecular Cell Biology, 2024 - nature.com
DNA methylation, also known as 5-methylcytosine, is an epigenetic modification that has
crucial functions in plant growth, development and adaptation. The cellular DNA methylation …
crucial functions in plant growth, development and adaptation. The cellular DNA methylation …
Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation
Background Cellular differentiation is marked by temporally and spatially coordinated gene
expression regulated at multiple levels. DNA methylation represents a universal mechanism …
expression regulated at multiple levels. DNA methylation represents a universal mechanism …
Structural insights into glucocorticoid receptor function
The glucocorticoid receptor (GR) is a steroid hormone-activated transcription factor that
binds to various glucocorticoid response elements to up-or down-regulate the transcription …
binds to various glucocorticoid response elements to up-or down-regulate the transcription …
Zinc metalloproteins in epigenetics and their crosstalk
More than half a century ago, zinc was established as an essential micronutrient for normal
human physiology. In silico data suggest that about 10% of the human proteome potentially …
human physiology. In silico data suggest that about 10% of the human proteome potentially …
Environmental adaptation of genetically uniform organisms with the help of epigenetic mechanisms—an insightful perspective on ecoepigenetics
G Vogt - Epigenomes, 2022 - mdpi.com
Organisms adapt to different environments by selection of the most suitable phenotypes from
the standing genetic variation or by phenotypic plasticity, the ability of single genotypes to …
the standing genetic variation or by phenotypic plasticity, the ability of single genotypes to …