For years, it has been recognized that the incidence of coronary heart disease (CHD) in
women lags behind that of men by≈ 10 years, 7 thus generating hypotheses that …

Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …

Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol
efflux, mediated by apolipoprotein AI, removes excess cholesterol from atherosclerotic …

Lecithin: cholesterol acyltransferase – from biochemistry to... : Current Opinion in
Endocrinology, Diabetes and Obesity Lecithin: cholesterol acyltransferase – from …

In recent years, engineering biocompatible HDL nanodiscs has garnered a great interest
with wide applications for for both drug delivery and structural biology. In this review, we …

High-density lipoprotein (HDL) is a key component of circulating blood and plays essential
roles in regulation of vascular endothelial function and immunity. Clinical data demonstrate …

We here present CLUES2, a full-likelihood method to infer natural selection from sequence
data that is an extension of the method CLUES. We make several substantial improvements …

Objective—The ability of apolipoprotein AI (apoA-I) to transport cholesterol from
atherosclerotic plaque is thought to underlie its inverse correlation with cardiovascular risk …

The goal of this study was to understand how the reconstituted HDL (rHDL) phospholipid
(PL) composition affects its cholesterol efflux and anti-inflammatory properties. An ApoA-I …

Since the seminal breakthrough of treating diabetic patients with insulin in the 1920s, there
has been great interest in developing other proteins and their peptide mimetics as therapies …