Resident memory T cells (T-RMs) remain in epithelial barrier tissues after antigen exposure
and the initial effector phase. These T-RMs provide effective antimicrobial and anticancer …

Tissue-resident memory T (T RM) cells serve as a first line of defense in peripheral tissues to
protect the organism against foreign pathogens. However, autoreactive T RM cells are …

Importance Psoriasis is a chronic inflammatory skin disease with unmet needs for tailored
treatment and therapy de-escalation strategies. Objective To evaluate early intervention with …

Introduction Given the chronic nature of psoriasis (PsO), more studies are needed that
directly compare the effectiveness of different biologics over long observation periods. This …

Risankizumab is a humanized monoclonal antibody that targets interleukin (IL-) 23,
approved for the treatment of moderate-to-severe plaque psoriasis, which has shown …

In the registration trial of risankizumab for patients with moderate‐to‐severe psoriasis in
Japan, similar Psoriasis Area Severity Index (PASI) responses were observed for 75 mg or …

As medicine advances, cures are being found for diseases that were previously considered
incurable, as is the case for some types of cancer. Traditionally, the term cure is reserved for …

Introduction The development of several effective biological drugs for moderate-to-severe
plaque psoriasis has dramatically changed the lives of patients. Despite the wide use of …

Introduction Knowing the remission duration after biologics discontinuation in patients with
psoriasis is important, especially when disease relapse is defined as the restart of systemic …

Background The anti-interleukin-23 antibody guselkumab (GUS) demonstrated favourable
week 24 efficacy and safety over fumaric acid esters (FAE) in systemic treatment-naïve …