Octa-methylpyridiloxy-substituted Zn (II)-and Ga (III)-phthalocyanines (ZnPc1 and GaPc1)
were studied on human pigmented melanoma (SH4) and keratinocyte (HaCaT) cell lines …

Cytokines are powerful mediators of immune responses and some, such as interleukin-2 (IL-
2), have achieved dramatic responses as cancer immunotherapies. Unfortunately, systemic …

The incidental detection of pancreatic cysts, an opportunity for the early detection of
pancreatic cancer, is increasing, owing to an aging population and improvements in imaging …

Two DO3A-type ligands conjugated to substrates of urokinase (L3) and caspase-3 (L4) via a
propyl-amide linker were synthesized and their lanthanide (III)(Ln3+) complexes studied. A …

Cancers have a complex relationship with the surrounding environment that regulates
everything from progression to response to treatment. Cell–cell and cell–matrix interactions …

Safety and efficacy of cancer-targeting treatments can be improved by conditional activation
enabled by the distinct milieu of the tumour microenvironment. Proteases are intricately …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due in part
to the cancer being diagnosed is at a late stage when effective treatment options are limited …

Objectives Dysregulation of proteolysis underlies diseases like cancer. Protease inhibitors
(PIs) regulate many biological functions and hence have potential anticancer properties …

Colorectal carcinogenesis is a complex process, which is linked to dysregulation of human
secretory phospholipases A2 (hsPLA2-G-IIA, hsPLA2-GV, and hsPLA2-GX), proteases …

Hyperhomocysteinemia (HHcy) is now being actively studied as a potential risk factor and/or
biomarker for numerous pathological conditions, including brain diseases. This study aimed …