Bioorthogonal chemistry for prodrug activation in vivo
Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …
Target‐Specific Bioorthogonal Reactions for Precise Biomedical Applications
Bioorthogonal chemistry is a promising toolbox for dissecting biological processes in the
native environment. Recently, bioorthogonal reactions have attracted considerable attention …
native environment. Recently, bioorthogonal reactions have attracted considerable attention …
Cancer therapy by nano MIL-n series of metal-organic frameworks
RK Alavijeh, K Akhbari - Coordination Chemistry Reviews, 2024 - Elsevier
In recent years, metal–organic frameworks (MOFs) have attracted attention for cancer
treatment. The MIL-n series is a popular sub-group of MOFs, which can be attributed to their …
treatment. The MIL-n series is a popular sub-group of MOFs, which can be attributed to their …
[HTML][HTML] Utilization of functionalized metal–organic framework nanoparticle as targeted drug delivery system for cancer therapy
Cancer is a multifaceted disease that results from the complex interaction between genetic
and environmental factors. Cancer is a mortal disease with the biggest clinical, societal, and …
and environmental factors. Cancer is a mortal disease with the biggest clinical, societal, and …
A Polyoxometalate‐Based Pathologically Activated Assay for Efficient Bioorthogonal Catalytic Selective Therapy
H Zhao, C Zhao, Z Liu, J Yi, X Liu… - Angewandte Chemie …, 2023 - Wiley Online Library
Since polyoxometalates (POMs) can undergo reversible multi‐electron redox
transformations, they have been used to modulate the electronic environment of metal …
transformations, they have been used to modulate the electronic environment of metal …
Accelerated Diffusion of a Copper (I)-Functionalized COF Packed Bed Reactor for Efficient Continuous Flow Catalysis
S Wang, X Xia, Q Chen, K Li, X Xiao… - ACS Applied Materials & …, 2024 - ACS Publications
Flow chemistry provides a neo-orientation for the research and development of chemical
technology, in which heterogeneous continuous catalysis based on packed beds can realize …
technology, in which heterogeneous continuous catalysis based on packed beds can realize …
Endogenous Enzyme-Activatable Spherical Nucleic Acids for Spatiotemporally Controlled Signal Amplification Molecular Imaging and Combinational Tumor Therapy
Y Zeng, R Peng, Y Hu, P Luo, R Yang, J Li… - Analytical …, 2023 - ACS Publications
Due to the adjustable hybridization activity, antinuclease digestion stability, and superior
endocytosis, spherical nucleic acids (SNAs) have been actively developed as probes for …
endocytosis, spherical nucleic acids (SNAs) have been actively developed as probes for …
Microfluidic Synthesis of CuH Nanoparticles for Antitumor Therapy through Hydrogen-Enhanced Apoptosis and Cuproptosis
G He, Y Pan, F Zeng, S Qin, X Luan, Q Lu, C Xie… - ACS …, 2024 - ACS Publications
Cuproptosis has drawn enormous attention in antitumor material fields; however, the
responsive activation of cuproptosis against tumors using nanomaterials with high atom …
responsive activation of cuproptosis against tumors using nanomaterials with high atom …
Advances of bioorthogonal coupling reactions in drug development
F Zhan, J Zhu, S Xie, J Xu, S Xu - European Journal of Medicinal Chemistry, 2023 - Elsevier
Currently, bioorthogonal coupling reactions have garnered considerable interest due to their
high substrate selectivity and less restrictive reaction conditions. During recent decades …
high substrate selectivity and less restrictive reaction conditions. During recent decades …
Sensitizing cuproptosis by endogenous copper-triggered bioorthogonal nanoremodeler
Cuproptosis, a copper-dependent cell death modality identified recently, provides a new
avenue for tumor treatment. However, the direct delivery of copper may disturb copper …
avenue for tumor treatment. However, the direct delivery of copper may disturb copper …