Bioorthogonal chemistry for prodrug activation in vivo

Q Fu, S Shen, P Sun, Z Gu, Y Bai, X Wang… - Chemical Society …, 2023 - pubs.rsc.org
Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …

Target‐Specific Bioorthogonal Reactions for Precise Biomedical Applications

Z Liu, M Sun, W Zhang, J Ren, X Qu - Angewandte Chemie, 2023 - Wiley Online Library
Bioorthogonal chemistry is a promising toolbox for dissecting biological processes in the
native environment. Recently, bioorthogonal reactions have attracted considerable attention …

Cancer therapy by nano MIL-n series of metal-organic frameworks

RK Alavijeh, K Akhbari - Coordination Chemistry Reviews, 2024 - Elsevier
In recent years, metal–organic frameworks (MOFs) have attracted attention for cancer
treatment. The MIL-n series is a popular sub-group of MOFs, which can be attributed to their …

[HTML][HTML] Utilization of functionalized metal–organic framework nanoparticle as targeted drug delivery system for cancer therapy

VA Tran, V Thuan Le, VD Doan, GNL Vo - Pharmaceutics, 2023 - mdpi.com
Cancer is a multifaceted disease that results from the complex interaction between genetic
and environmental factors. Cancer is a mortal disease with the biggest clinical, societal, and …

A Polyoxometalate‐Based Pathologically Activated Assay for Efficient Bioorthogonal Catalytic Selective Therapy

H Zhao, C Zhao, Z Liu, J Yi, X Liu… - Angewandte Chemie …, 2023 - Wiley Online Library
Since polyoxometalates (POMs) can undergo reversible multi‐electron redox
transformations, they have been used to modulate the electronic environment of metal …

Accelerated Diffusion of a Copper (I)-Functionalized COF Packed Bed Reactor for Efficient Continuous Flow Catalysis

S Wang, X Xia, Q Chen, K Li, X Xiao… - ACS Applied Materials & …, 2024 - ACS Publications
Flow chemistry provides a neo-orientation for the research and development of chemical
technology, in which heterogeneous continuous catalysis based on packed beds can realize …

Endogenous Enzyme-Activatable Spherical Nucleic Acids for Spatiotemporally Controlled Signal Amplification Molecular Imaging and Combinational Tumor Therapy

Y Zeng, R Peng, Y Hu, P Luo, R Yang, J Li… - Analytical …, 2023 - ACS Publications
Due to the adjustable hybridization activity, antinuclease digestion stability, and superior
endocytosis, spherical nucleic acids (SNAs) have been actively developed as probes for …

Microfluidic Synthesis of CuH Nanoparticles for Antitumor Therapy through Hydrogen-Enhanced Apoptosis and Cuproptosis

G He, Y Pan, F Zeng, S Qin, X Luan, Q Lu, C Xie… - ACS …, 2024 - ACS Publications
Cuproptosis has drawn enormous attention in antitumor material fields; however, the
responsive activation of cuproptosis against tumors using nanomaterials with high atom …

Advances of bioorthogonal coupling reactions in drug development

F Zhan, J Zhu, S Xie, J Xu, S Xu - European Journal of Medicinal Chemistry, 2023 - Elsevier
Currently, bioorthogonal coupling reactions have garnered considerable interest due to their
high substrate selectivity and less restrictive reaction conditions. During recent decades …

Sensitizing cuproptosis by endogenous copper-triggered bioorthogonal nanoremodeler

J Zhu, Y You, W Zhang, W Wang, M Jiang, F Pu, J Ren… - Nano Today, 2024 - Elsevier
Cuproptosis, a copper-dependent cell death modality identified recently, provides a new
avenue for tumor treatment. However, the direct delivery of copper may disturb copper …