The microenvironment (local environment), including viscosity, temperature, polarity,
hypoxia, and acidic-basic status (pH), plays indispensable roles in cellular processes …

Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that
integrates the advantage of optical and acoustic imaging, has great application prospects in …

Bioactive species, including reactive oxygen species (ROS, including O2˙−, H2O2, HOCl,
1O2,˙ OH, HOBr, etc.), reactive nitrogen species (RNS, including ONOO−, NO, NO2, HNO …

Polarity, as a complex parameter, plays pivotal roles in chemistry and biology. Deviant
polarity change in different subcellular compartments is closely connected with diseases …

Fluorescence and photoacoustic imaging have different advantages in cancer diagnosis;
however, combining effects in one agent normally requires a trade-off as the mechanisms …

Immunogenic cell death (ICD) can activate the anticancer immune response and is highly
attractive to improve cancer treatment efficacy. ICD is closely related to endoplasmic …

Excessive production of oxidative species alters the normal redox balance and leads to
diseases, such as chronic inflammation and cancer. Oxidative species are short‐lived …

Hypochlorous acid (HOCl), a well-known universal disinfectant in clinical practice, plays
important roles in immune systems of animal and human bodies. For understanding the …

As a new form of regulated cell death, ferroptosis is closely related to various diseases. To
interpret this biological behavior and monitor related pathological processes, it is necessary …

Most photoacoustic (PA) imaging agents are based on the repurposing of existing
fluorescent dye platforms that exhibit non‐optimal properties for PA applications. Herein, we …