Given the" inborn" nature of the innate immune system, it is surprising to find that innate
immune function does in fact change with age. Similar patterns of distinct Toll-like-receptor …

It is widely accepted that the brain and the immune system continuously interact during
normal as well as pathological functioning. Human aging is commonly accompanied by low …

Deriving disease subtypes from electronic health records (EHRs) can guide next-generation
personalized medicine. However, challenges in summarizing and representing patient data …

Background Increased exposure to intestinal bacterial products may contribute to the
pathogenesis of non alcoholic steatohepatitis (NASH). Bifidobacteria are predominant …

Background Monoclonal antibodies (mAb) targeting PD‐1/PD‐L1 have revolutionized
melanoma treatment, yet data regarding effectiveness and tolerability across age groups is …

The role of chemokines has been extensively analyzed both in cancer risk and tumor
progression. Among different cytokines, CXCR4 and its ligand CXCL12 have been recently …

Cancer stem cell (CSC) biology and tumor immunology have shaped our understanding of
tumorigenesis. However, we still do not fully understand why tumors can be contained but …

Background The hepatocellular carcinoma is one of the most common malignant tumors and
carries a poor survival rate. The management of patients at risk for developing HCC remains …

Age is the most important risk factor for tumorigenesis. More than 60% of new cancers and
more than 70% of cancer deaths occur in elderly subjects> 65 years. The immune system …

Early, sustained ART is a crucial component of cancer prevention. Continued epidemiologic
monitoring is needed to detect possible effects on cancer risk of specific ART classes or …