Definitive chemoradiotherapy (dCRT) for the esophageal squamous cell carcinoma (ESCC)
is performed for patients with cT4 disease without distant metastasis and also for those with …

Objective: The aim of this study was to evaluate primary tumor (PT) and lymph node (LN)
responses to neoadjuvant chemotherapy (NACT) for predicting long-term survival in patients …

Background The optimal treatment approach for T4 esophageal cancer is not well
established. We aimed to perform a systematic review and meta-analysis to determine the …

Importance Esophageal cancer remains one of the most deadly cancers, ranking sixth
highest among cancers leading to the greatest years of life lost. Objective To determine how …

Background Lymphovascular invasion (LVI) was previously reported to be an independent
factor associated with survival in locally advanced esophageal squamous cell carcinoma …

Background Patients with esophageal cancer that invades adjacent structures (cT4b) are
precluded from surgery and usually treated with definitive chemoradiotherapy (dCRT). dCRT …

Background The optimal treatment strategy for cT4b esophageal cancer has not been
established yet. Although curative surgery is sometimes performed after induction …

Background This study aimed to investigate an unsettled issue that whether T4 esophageal
cancer could benefit from surgery. Methods Patients with T4N0-3M0 esophageal cancer …

Purpose The present study aimed to evaluate the long-term results of definitive
chemoradiotherapy (CRT) for unresectable locally advanced esophageal squamous cell …

Background Locally advanced esophageal cancer (EC) invading surrounding organs (T4b)
is difficult to treat. In general, definitive chemoradiotherapy (d-CRT) has been chosen as …