Human disease variation in the light of population genomics
Identifying the causes of similarities and differences in genetic disease prevalence among
humans is central to understanding disease etiology. While present-day humans are not …
humans is central to understanding disease etiology. While present-day humans are not …
The human blood transcriptome exhibits time-of-day-dependent response to hypoxia: Lessons from the highest city in the world
High altitude exposes humans to hypobaric hypoxia, which induces various physiological
and molecular changes. Recent studies point toward interaction between circadian rhythms …
and molecular changes. Recent studies point toward interaction between circadian rhythms …
The role of nitrogen oxides in human adaptation to hypoxia
Lowland residents adapt to the reduced oxygen availability at high altitude through a
process known as acclimatisation, but the molecular changes underpinning these functional …
process known as acclimatisation, but the molecular changes underpinning these functional …
Energy metabolism and the high‐altitude environment
AJ Murray - Experimental physiology, 2016 - Wiley Online Library
New Findings What is the topic of this review? This report describes changes in cardiac and
skeletal muscle energy metabolism that occur with exposure to high altitude and considers …
skeletal muscle energy metabolism that occur with exposure to high altitude and considers …
Physiological genomics of adaptation to high-altitude hypoxia
JF Storz, ZA Cheviron - Annual Review of Animal Biosciences, 2021 - annualreviews.org
Population genomic studies of humans and other animals at high altitude have generated
many hypotheses about the genes and pathways that may have contributed to hypoxia …
many hypotheses about the genes and pathways that may have contributed to hypoxia …
Green standard and green development: Theory and empirical evidence
W Xiong, X Guo, Y Sun, JJ Ou - Journal of Cleaner Production, 2023 - Elsevier
This study uses panel data from China spanning from 1999 to 2019 to construct the green
standard development index and the green development index using Principal Component …
standard development index and the green development index using Principal Component …
Hypoxia downregulates protein S expression
While this manuscript was in preparation, another group of investigators also studied the
utility of normalizing plasma hepcidin to the TfSat in patients with IRIDA. 6 In particular, they …
utility of normalizing plasma hepcidin to the TfSat in patients with IRIDA. 6 In particular, they …
Increased cerebral output of free radicals during hypoxia: implications for acute mountain sickness?
This study examined whether hypoxia causes free radical-mediated disruption of the blood-
brain barrier (BBB) and impaired cerebral oxidative metabolism and whether this has any …
brain barrier (BBB) and impaired cerebral oxidative metabolism and whether this has any …
[HTML][HTML] Placental physioxia is based on spatial and temporal variations of placental oxygenation throughout pregnancy
B Huppertz - Journal of Reproductive Immunology, 2023 - Elsevier
For obvious reasons, in vivo measurements of placental oxygenation are extremely rare and
hence, scientists need to focus on the few studies that revealed at least some data on the …
hence, scientists need to focus on the few studies that revealed at least some data on the …
Role of mitochondria‐associated endoplasmic reticulum membrane in inflammation‐mediated metabolic diseases
Inflammation is considered to be one of the most critical factors involved in the development
of complex metabolic diseases such as type 2 diabetes, cancer, and cardiovascular disease …
of complex metabolic diseases such as type 2 diabetes, cancer, and cardiovascular disease …