Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

Background Papillary renal-cell carcinoma, which accounts for 15 to 20% of renal-cell
carcinomas, is a heterogeneous disease that consists of various types of renal cancer …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

Oxidative stress due to imbalance between ROS production and detoxification plays a
pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling …

An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …

Organismal life encounters reactive oxidants from internal metabolism and environmental
toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are …

The notion that electrophiles serve as messengers in cell signaling is now widely accepted.
Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as …

Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …