Menopause-related decline in estrogen levels is accompanied by a change in adipose
tissue distribution from a gynoid to an android and an increased prevalence of obesity in …

NASH is within the spectrum of NAFLD, a liver condition encompassing liver steatosis,
inflammation, hepatocyte injury, and fibrosis. The prevalence of NASH-induced cirrhosis is …

Endocrine resistance remains a significant problem in the clinical treatment of estrogen
receptor α-positive (ERα+) breast cancer (BC). In this study, we developed a series of novel …

Aging entails the inevitable loss of the structural and functional integrity of cells and tissues
during the lifetime. It is a highly hormone-dependent process; although, the exact …

Breast cancer remains the most frequently diagnosed cancer in women worldwide. Tumors
that express hormone receptors account for 75% of all cases. Understanding alternative …

Background Other than for breast cancer, endocrine therapy has not been highly effective for
gynecologic cancers. Endocrine therapy resistance in estrogen receptor positive …

Simple Summary The study discusses the potential of targeting transcription factors (TFs) for
cancer therapy and provide a systematic classification of various types of TFs involved in the …

DDT and its transformation products (DDTs) are frequently detected in environmental and
biological media. Research suggests that DDT and its primary metabolites (DDD and DDE) …

Prostate cancer (PCa) is today the second most common cancer in the world, with almost
400,000 deaths annually. Multiple factors are involved in the etiology of PCa, such as older …

The estrogen receptor beta (ERβ) is physiologically essential for reproductive biology and is
implicated in various diseases. However, despite more than 20 years of intensive research …