Network Pharmacology and Bioinformatics Approach Reveals the Multi-Target Pharmacological Mechanism of Fumaria indica in the Treatment of Liver Cancer

S Batool, MR Javed, S Aslam, F Noor, HMF Javed… - Pharmaceuticals, 2022 - mdpi.com
Liver cancer (LC), a frequently occurring cancer, has become the fourth leading cause of
cancer mortality. The small number of reported data and diverse spectra of …

Molecular bioprospection of Helianthus annuus L.(sunflower) cypsela for antidiabetic therapeutics through network pharmacology, density functional theory and …

A Rampadarath, JO Aribisala, NP Makunga… - South African Journal of …, 2023 - Elsevier
Helianthus annuus cypsela (sunflower) is a staple oilseed crop with significant therapeutic
applications against diverse diseases including type 2 diabetes mellitus (T2DM). Despite its …

Network Pharmacology- and Molecular Dynamics Simulation-Based Bioprospection of Aspalathus linearis for Type-2 Diabetes Care

A Akoonjee, A Rampadarath, CE Aruwa, TA Ajiboye… - Metabolites, 2022 - mdpi.com
The medicinal herb Aspalathus linearis (rooibos) is globally recognized in type-2 diabetes
mellitus (T2DM) treatment due to its known and distinctive compounds. This work utilized …

Agathis robusta Bark Extract Protects from Renal Ischemia-Reperfusion Injury: Phytochemical, In Silico and In Vivo Studies

ME Mohamed, N Tawfeek, SS Elbaramawi… - Pharmaceuticals, 2022 - mdpi.com
Background: Acute kidney injury (AKI) induced by renal ischemia-reperfusion injury (RIRI) is
associated with a high incidence of mortality. Existing therapies are mainly supportive, with …

Waste to Medicine: Evidence from Computational Studies on the Modulatory Role of Corn Silk on the Therapeutic Targets Implicated in Type 2 Diabetes Mellitus

A Akoonjee, AA Lanrewaju, FO Balogun, NP Makunga… - Biology, 2023 - mdpi.com
Simple Summary Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance
and/or defective insulin production in the human body. Corn silk (CS), an abundant, readily …

Insights into the Mechanism of Action of Helianthus annuus (Sunflower) Seed Essential Oil in the Management of Type-2 Diabetes Mellitus Using Network …

A Rampadarath, FO Balogun, S Sabiu - Endocrines, 2023 - mdpi.com
Type-2 diabetes mellitus (T2D) is one of the leading non-communicable diseases of global
concern. Knowing the exact mechanism of action of available antidiabetic agents …

A Review of Antidiabetic Medicinal Plants as a Novel Source of Phosphodiesterase Inhibitors: Future Perspective of New Challenges Against Diabetes Mellitus

H Ouassou, N Elhouda Daoudi, S Bouknana… - Medicinal …, 2024 - ingentaconnect.com
Intracellular glucose concentration plays a crucial role in initiating the molecular secretory
process of pancreatic β-cells through multiple messengers and signaling pathways. Cyclic …

Phenolic profiles and in vitro biochemical properties of Thai herb ingredients for chronic diseases prevention

N On-Nom, S Thangsiri, W Inthachat… - Scientific Reports, 2023 - nature.com
Traditional remedies using natural ingredients have been handed down over generations,
providing collective information for the development of modern therapeutics. These natural …

Phenotypic plasticity promotes lymph nodes metastasis and drug resistance in lung squamous cell carcinomas

F Wang, L Zhu - Heliyon, 2023 - cell.com
Background Phenotypic plasticity (PP) is a major promoter of tumor metastasis and drug
resistance. Nevertheless, the molecular features and clinical significance of phenotypic …

Parametric Study and Characterization of Sappan Wood (Caesalpinia Sappan Linn) Natural Red Colorant Extract with Ultrasonic Assisted Extraction Method

Y Yuniati, DD Azmi, E Nurandriea… - ASEAN Journal of …, 2023 - journal.ugm.ac.id
In this study, the optimization and characterization of the colorant extraction process from
sappan wood were carried out using the ultrasound-assisted extraction method. Sappan is …