Antidepressant drugs as emerging contaminants: Occurrence in urban and non-urban waters and analytical methods for their detection
C Castillo-Zacarías, ME Barocio… - Science of the Total …, 2021 - Elsevier
Antidepressants are drugs with a direct action on the brain's biochemistry through their
interaction with the neurotransmitters, such as dopamine, norepinephrine, and serotonin …
interaction with the neurotransmitters, such as dopamine, norepinephrine, and serotonin …
Brain NMDA receptors in schizophrenia and depression
A Adell - Biomolecules, 2020 - mdpi.com
N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …
[HTML][HTML] Efficient detection and treatment of pharmaceutical contaminants to produce clean water for better health and environmental
The influx of emerging, prescribed, and FDA approved pharmaceutical contaminants (PCs)
in the environment is continuously affecting human health and human cycle (even at trace …
in the environment is continuously affecting human health and human cycle (even at trace …
Ketamine and the future of rapid-acting antidepressants
The therapeutic onset of traditional antidepressants is delayed by several weeks and many
depressed patients fail to respond to treatment altogether. In contrast, subanesthetic …
depressed patients fail to respond to treatment altogether. In contrast, subanesthetic …
When pharmaceutical drugs become environmental pollutants: Potential neural effects and underlying mechanisms
Pharmaceutical drugs have become consumer products, with a daily use for some of them.
The volume of production and consumption of drugs is such that they have become …
The volume of production and consumption of drugs is such that they have become …
Antidepressants as emerging contaminants: Occurrence in wastewater treatment plants and surface waters in Hangzhou, China
Y Chen, J Wang, P Xu, J Xiang, D Xu… - Frontiers in Public …, 2022 - frontiersin.org
Aims Antidepressants have aroused wide public concern due to their widespread presence
in water and their harm to human health and environment. This study was designed to …
in water and their harm to human health and environment. This study was designed to …
[HTML][HTML] Rodent ketamine depression-related research: finding patterns in a literature of variability
Discovering that the anesthetic drug ketamine has rapidly acting antidepressant effects in
many individuals with major depression is one of the most important findings in clinical …
many individuals with major depression is one of the most important findings in clinical …
Effects of acute and chronic administration of trace amine-associated receptor 1 (TAAR1) ligands on in vivo excitability of central monoamine-secreting neurons in rats
D Grinchii, MC Hoener, T Khoury, R Dekhtiarenko… - Molecular …, 2022 - nature.com
Trace amine-associated receptor 1 (TAAR1) has been recently identified as a target for the
future antidepressant, antipsychotic, and anti-addiction drugs. Full (eg RO5256390) and …
future antidepressant, antipsychotic, and anti-addiction drugs. Full (eg RO5256390) and …
The effect of ketamine and D-cycloserine on the high frequency resting EEG spectrum in humans
JF Nottage, A Gabay, K De Meyer, KF Herrik… - …, 2023 - Springer
Rationale Preclinical studies indicate that high-frequency oscillations, above 100 Hz (HFO:
100–170 Hz), are a potential translatable biomarker for pharmacological studies, with the …
100–170 Hz), are a potential translatable biomarker for pharmacological studies, with the …
R (−)-methoxetamine exerts rapid and sustained antidepressant effects and fewer behavioral side effects relative to S (+)-methoxetamine
The newfound antidepressant efficacy of ketamine has provided opportunities for the
development of new-generation, rapid-acting, glutamate-based antidepressants. We …
development of new-generation, rapid-acting, glutamate-based antidepressants. We …