[HTML][HTML] Muscle Structure Influences Utrophin Expression in mdx Mice
GB Banks, AC Combs, GL Odom, RJ Bloch… - PLoS …, 2014 - journals.plos.org
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disorder caused by
mutations in the dystrophin gene. To examine the influence of muscle structure on the …
mutations in the dystrophin gene. To examine the influence of muscle structure on the …
Soluble vascular endothelial glycocalyx proteoglycans as potential therapeutic targets in inflammatory diseases
M Kunnathattil, P Rahul, T Skaria - Immunology and Cell …, 2024 - Wiley Online Library
Reducing the activity of cytokines and leukocyte extravasation is an emerging therapeutic
strategy to limit tissue‐damaging inflammatory responses and restore immune homeostasis …
strategy to limit tissue‐damaging inflammatory responses and restore immune homeostasis …
[HTML][HTML] Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models
LGM Heezen, T Abdelaal, M Van Putten… - Nature …, 2023 - nature.com
Duchenne muscular dystrophy is caused by mutations in the DMD gene, leading to lack of
dystrophin. Chronic muscle damage eventually leads to histological alterations in skeletal …
dystrophin. Chronic muscle damage eventually leads to histological alterations in skeletal …
Recombinant production of proteoglycans and their bioactive domains
MS Lord, JM Whitelock - The FEBS journal, 2013 - Wiley Online Library
Proteoglycans are ubiquitous dynamic molecules that are made up of a protein core to
which specific linear glycosylation structures, known as glycosaminoglycans, have been …
which specific linear glycosylation structures, known as glycosaminoglycans, have been …
The cytoprotective effect of biglycan core protein involves Toll-like receptor 4 signaling in cardiomyocytes
Aims Exogenously administered biglycan (core protein with high-molecular weight
glycosaminoglycan chains) has been shown to protect neonatal cardiomyocytes against …
glycosaminoglycan chains) has been shown to protect neonatal cardiomyocytes against …
MuSK is a BMP co-receptor that shapes BMP responses and calcium signaling in muscle cells
Bone morphogenetic proteins (BMPs) function in most tissues but have cell type–specific
effects. Given the relatively small number of BMP receptors, this exquisite signaling …
effects. Given the relatively small number of BMP receptors, this exquisite signaling …
Large-scale opening of utrophin's tandem calponin homology (CH) domains upon actin binding by an induced-fit mechanism
AY Lin, E Prochniewicz, ZM James… - Proceedings of the …, 2011 - National Acad Sciences
We have used site-directed spin labeling and pulsed electron paramagnetic resonance to
resolve a controversy concerning the structure of the utrophin–actin complex, with …
resolve a controversy concerning the structure of the utrophin–actin complex, with …
[HTML][HTML] Optimized lentiviral vector to restore full-length dystrophin via a cell-mediated approach in a mouse model of Duchenne muscular dystrophy
J Meng, M Moore, J Counsell, F Muntoni… - … Therapy-Methods & …, 2022 - cell.com
Duchenne muscular dystrophy (DMD) is a muscle wasting disorder caused by mutations in
the DMD gene. Restoration of full-length dystrophin protein in skeletal muscle would have …
the DMD gene. Restoration of full-length dystrophin protein in skeletal muscle would have …
[HTML][HTML] Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle
TL Kennedy, L Moir, S Hemming, B Edwards, S Squire… - Skeletal muscle, 2017 - Springer
Background Duchenne muscular dystrophy (DMD) is a lethal X-linked muscle wasting
disorder caused by the absence of dystrophin, a large cytoskeletal muscle protein …
disorder caused by the absence of dystrophin, a large cytoskeletal muscle protein …
Celecoxib treatment improves muscle function in mdx mice and increases utrophin A expression
C Péladeau, NJ Adam, BJ Jasmin - The FASEB Journal, 2018 - Wiley Online Library
Duchenne muscular dystrophy (DMD) is a genetic and progressive neuromuscular disorder
caused by mutations and deletions in the dystrophin gene. Although there is currently no …
caused by mutations and deletions in the dystrophin gene. Although there is currently no …