[HTML][HTML] Muscle Structure Influences Utrophin Expression in mdx Mice

GB Banks, AC Combs, GL Odom, RJ Bloch… - PLoS …, 2014 - journals.plos.org
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disorder caused by
mutations in the dystrophin gene. To examine the influence of muscle structure on the …

Soluble vascular endothelial glycocalyx proteoglycans as potential therapeutic targets in inflammatory diseases

M Kunnathattil, P Rahul, T Skaria - Immunology and Cell …, 2024 - Wiley Online Library
Reducing the activity of cytokines and leukocyte extravasation is an emerging therapeutic
strategy to limit tissue‐damaging inflammatory responses and restore immune homeostasis …

[HTML][HTML] Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models

LGM Heezen, T Abdelaal, M Van Putten… - Nature …, 2023 - nature.com
Duchenne muscular dystrophy is caused by mutations in the DMD gene, leading to lack of
dystrophin. Chronic muscle damage eventually leads to histological alterations in skeletal …

Recombinant production of proteoglycans and their bioactive domains

MS Lord, JM Whitelock - The FEBS journal, 2013 - Wiley Online Library
Proteoglycans are ubiquitous dynamic molecules that are made up of a protein core to
which specific linear glycosylation structures, known as glycosaminoglycans, have been …

The cytoprotective effect of biglycan core protein involves Toll-like receptor 4 signaling in cardiomyocytes

R Gáspár, M Pipicz, F Hawchar, D Kovács… - Journal of molecular and …, 2016 - Elsevier
Aims Exogenously administered biglycan (core protein with high-molecular weight
glycosaminoglycan chains) has been shown to protect neonatal cardiomyocytes against …

MuSK is a BMP co-receptor that shapes BMP responses and calcium signaling in muscle cells

A Yilmaz, C Kattamuri, RN Ozdeslik, C Schmiedel… - Science …, 2016 - science.org
Bone morphogenetic proteins (BMPs) function in most tissues but have cell type–specific
effects. Given the relatively small number of BMP receptors, this exquisite signaling …

Large-scale opening of utrophin's tandem calponin homology (CH) domains upon actin binding by an induced-fit mechanism

AY Lin, E Prochniewicz, ZM James… - Proceedings of the …, 2011 - National Acad Sciences
We have used site-directed spin labeling and pulsed electron paramagnetic resonance to
resolve a controversy concerning the structure of the utrophin–actin complex, with …

[HTML][HTML] Optimized lentiviral vector to restore full-length dystrophin via a cell-mediated approach in a mouse model of Duchenne muscular dystrophy

J Meng, M Moore, J Counsell, F Muntoni… - … Therapy-Methods & …, 2022 - cell.com
Duchenne muscular dystrophy (DMD) is a muscle wasting disorder caused by mutations in
the DMD gene. Restoration of full-length dystrophin protein in skeletal muscle would have …

[HTML][HTML] Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle

TL Kennedy, L Moir, S Hemming, B Edwards, S Squire… - Skeletal muscle, 2017 - Springer
Background Duchenne muscular dystrophy (DMD) is a lethal X-linked muscle wasting
disorder caused by the absence of dystrophin, a large cytoskeletal muscle protein …

Celecoxib treatment improves muscle function in mdx mice and increases utrophin A expression

C Péladeau, NJ Adam, BJ Jasmin - The FASEB Journal, 2018 - Wiley Online Library
Duchenne muscular dystrophy (DMD) is a genetic and progressive neuromuscular disorder
caused by mutations and deletions in the dystrophin gene. Although there is currently no …