Background Tendon injuries amount to one of the leading causes of career-ending injuries
in horses due to the inability for tendon to completely repair and the high reinjury potential …

Key points Adeno‐associated viral vector was used to elevate the expression of muscle
specific kinase (MuSK) and rapsyn (a cytoplasmic MuSK effector protein) in the tibialis …

Skeletal muscle possesses a robust innate capability for repair of tissue damage. Natural
repair of muscle damage is a stepwise process that requires the coordinated activity of a …

Duchenne muscular dystrophy (DMD) is an inherited fatal X-linked myogenic disorder with a
prevalence of 1 in 3500 male live births. It affects voluntary muscles, and heart and …

Duchenne muscular dystrophy (DMD) is a serious genetic neuromuscular rare disease that
is prevalent and caused by the mutation/deletion of the X-linked DMD gene that encodes …

The intervertebral disc (IVD) is responsible for normal spinal motion and load distribution.
However, degeneration may occur due to age‐and non‐age‐related processes and is …

Key points Muscular dystrophy patients suffer from progressive degeneration of skeletal
muscle fibres, sudden spontaneous falls, balance problems, as well as gait and posture …

It is becoming increasingly clear that genomics is beginning to have a major impact in
guiding diagnoses and treatment of many disorders. As the cost of DNA sequencing …

The field of pharmacological therapies for the muscular dystrophies continues to steadily
advance. It is encouraging that research into new therapies is increasingly exploring …

Decorin is a member of the small leucine-rich proteoglycan family and it is a component of
the extracellular matrix. Decorin was previously shown to bind different molecules, including …