The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

Objective—The present study was conducted to investigate the contribution of perivascular
adipose tissue (PVAT) to vascular dysfunction in a mouse model of diet-induced obesity …

Endothelial nitric oxide synthase (eNOS) plays an essential role in the regulation of
endothelial function and acts as a master regulator of vascular tone and homeostasis …

Abstract Arginase (EC 3.5. 3.1) is the bimanganese enzyme that converts L‐arginine into
ornithine and urea. This enzyme was discovered more than a century ago and early α …

Background: Experimental trials suggest improved outcome by mild therapeutic hypothermia
for cardiogenic shock after acute myocardial infarction. The objective of this study was to …

Highlights•Arginase plays a key role in the development of asthma and COPD.•Disrupted l-
arginine homeostasis may contribute to the emergence of co-morbidities.•Local use of …

Emerging studies provide new data shedding some light on the complex and pivotal role of
red blood cells (RBCs) in nitric oxide (NO) metabolism and paracrine regulation of …