Technological developments in lncRNA biology
S Jathar, V Kumar, J Srivastava, V Tripathi - Long Non Coding RNA …, 2017 - Springer
It is estimated that more than 90% of the mammalian genome is transcribed as non-coding
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …
Competing endogenous RNA: the key to posttranscriptional regulation
Competing endogenous RNA, ceRNA, vie with messenger RNAs (mRNAs) for microRNAs
(miRNAs) with shared miRNAs responses elements (MREs) and act as modulator of miRNA …
(miRNAs) with shared miRNAs responses elements (MREs) and act as modulator of miRNA …
[HTML][HTML] LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619 …
C Zhou, C Yi, Y Yi, W Qin, Y Yan, X Dong, X Zhang… - Molecular cancer, 2020 - Springer
Background Pancreatic cancer is one of the most lethal malignancies and has an extremely
poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major …
poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major …
Phase separation of RNA-binding protein promotes polymerase binding and transcription
An RNA-involved phase-separation model has been proposed for transcription control.
However, the molecular links that connect RNA to the transcription machinery remain …
However, the molecular links that connect RNA to the transcription machinery remain …
[HTML][HTML] LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9
Z Fu, C Chen, Q Zhou, Y Wang, Y Zhao, X Zhao, W Li… - Cancer letters, 2017 - Elsevier
Our previous study demonstrated that long non-coding RNA (lncRNA) HOTTIP was
maximally expressed in PDAC, and promoted cancer cell progression and epithelial to …
maximally expressed in PDAC, and promoted cancer cell progression and epithelial to …
Negative regulation of the interferon response by an interferon-induced long non-coding RNA
H Kambara, F Niazi, L Kostadinova… - Nucleic acids …, 2014 - academic.oup.com
Long non-coding RNAs (lncRNAs) play critical roles in diverse cellular processes; however,
their involvement in many critical aspects of the immune response including the interferon …
their involvement in many critical aspects of the immune response including the interferon …
[HTML][HTML] MEG3 long noncoding RNA contributes to the epigenetic regulation of epithelial-mesenchymal transition in lung cancer cell lines
M Terashima, S Tange, A Ishimura, T Suzuki - Journal of Biological …, 2017 - ASBMB
Histone methylation is implicated in a number of biological and pathological processes,
including cancer development. In this study, we investigated the molecular mechanism for …
including cancer development. In this study, we investigated the molecular mechanism for …
Long non‐coding RNA regulation of reproduction and development
Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene
regulation. Studies conducted over a decade ago revealed that maturation of spliced …
regulation. Studies conducted over a decade ago revealed that maturation of spliced …
[HTML][HTML] A pathophysiological view of the long non-coding RNA world
F Di Gesualdo, S Capaccioli, M Lulli - Oncotarget, 2014 - ncbi.nlm.nih.gov
Because cells are constantly exposed to micro-environmental changes, they require the
ability to adapt to maintain a dynamic equilibrium. Proteins are considered critical for the …
ability to adapt to maintain a dynamic equilibrium. Proteins are considered critical for the …
[HTML][HTML] The lncRNA MIR31HG regulates p16INK4A expression to modulate senescence
Oncogene-induced senescence (OIS) can occur in response to oncogenic insults and is
considered an important tumour suppressor mechanism. Here we identify the lncRNA …
considered an important tumour suppressor mechanism. Here we identify the lncRNA …