β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial
agents for treating both Gram-negative and Gram-positive bacterial infections. The β-lactam …

The emergence of antimicrobial-resistant infections is still a major concern for public health
worldwide. The number of pathogenic microorganisms capable of resisting common …

Antimicrobial peptides (AMPs) exhibit mighty antibacterial properties without inducing drug
resistance. Achieving much higher selectivity of AMPs towards bacteria and normal cells has …

Multidrug-resistant bacteria infections pose an increasingly serious threat to human health,
and the development of antimicrobials is far from meeting the clinical demand. It is urgent to …

Insect defensins are a large family of antimicrobial peptides primarily active against Gram-
positive bacteria. Here, we explore their hidden anti-Gram-negative bacterial potential via a …

Gram-negative sepsis has become a substantial and escalating global healthcare challenge
due to the growing antibiotic resistance crisis and the sluggish development of new …

Staphylococcus aureus (S. aureus) is one of the most common food-borne poisoning
microbial agent. However, the antimicrobial activity of β-defensin 116 in yak and its …

Helicobacter pylori has a unique lipopolysaccharide structure that is essential in maintaining
its cell envelope integrity and imbues the bacterium with natural resistance to cationic …

Rationale: Antimicrobial peptide LL-37 has been recognized as a favorable alternative to
antibiotics due to its broad antibacterial spectrum, low resistance development and diverse …

An innate immune system intricately leverages unique mechanisms to inhibit colonization of
external invasive Bacteria, for example human defensin-6, through responsive …