Colorectal cancer (CRC) is a common gastrointestinal malignancy with higher incidence
and mortality rates in men compared to women, potentially due to the effects of estrogen …

Background Tolerability and antitumour efficacy of chemotherapy and radiation therapy can
vary largely according to their time of administration along the 24-h time scale, due to the …

Neglecting sex and gender in research is a public-health risk Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Background Timing drug administration to endogenous circadian rhythms may enhance
treatment efficacy. In the Chronotype sub-study of the Treatment in Morning versus Evening …

The reviews in Volume 64 of the Annual Review of Pharmacology and Toxicology cover
diverse topics. A common theme in many of the reviews is the interindividual variability in the …

Introduction The 24-hour variations in drug absorption, distribution, metabolism, and
elimination, collectively known as pharmacokinetics, are fundamentally influenced by …

All organisms have various circadian, behavioral, and physiological 24-h periodic rhythms,
which are controlled by the circadian clock. The circadian clock controls various behavioral …

The growing numbers of cancer cases represent a medical and societal burden worldwide.
More than half of all cancer patients are treated with chemotherapy. Yet, chemotherapeutic …

Strong circadian (~ 24h) rhythms in heart rate (HR) are critical for flexible regulation of
cardiac pacemaking function throughout the day. While this circadian flexibility in HR is …

The circadian rhythm is necessary for the homeostasis and health of living organisms.
Molecular clocks interconnected by transcription/translation feedback loops exist in most …