Increasing evidence of a role of chronic inflammation in type 2 diabetes progression has led
to the development of therapies targeting the immune system. We develop a model of …

BACKGROUND & AIMS: Chronic pancreatitis (CP) often leads to the development of
diabetes. To understand better this pathogenic mechanism, we investigated whether islet …

Abstract The Banting Medal for Scientific Achievement Award is the American Diabetes
Association's highest scientific award and honors an individual who has made significant …

Pancreatic β cell expansion and functional maturation during the birth-to-weaning period is
driven by epigenetic programs primarily triggered by growth factors, hormones, and nutrients …

The factors controlling linear growth and weight gain in the human fetus and newborn infant
are poorly understood. We review here the changes in linear growth, weight gain, lean body …

There are three types of cell death; apoptosis, necrosis, and autophagy. The possibility that
activation of the macroautophagy (autophagy) pathway may increase beta cell death is …

A heterozygous missense mutation of the islet β cell-enriched MAFA transcription factor (p.
Ser64Phe [S64F]) is found in patients with adult-onset β cell dysfunction (diabetes or …

As we previously demonstrated, there is an adaptive increase in insulin secretion in insulin
resistance in the model of high-fat fed female mice. Since it is assumed that islets also adapt …

Pancreatic islet cell regeneration is considered to be important in the onset and progression
of diabetes and as a potential cell therapy. Current hypotheses, largely based on rodent …

Ageing is generally associated with deterioration of organ function and regenerative
potential. In the case of pancreatic β‐cells, an age‐related decline in proliferative potential is …