Hemophagocytic syndrome (HPS) or hemophagocytic lymphohistiocytosis (HLH) is an acute
and rapidly progressive systemic inflammatory disorder characterized by cytopenia …

Granzyme B is a caspase-like serine protease that is released by cytotoxic lymphocytes to
kill virus-infected and tumor cells. Major recent advances in our understanding of granzyme …

A variety of neutral serine proteases are important for the effector functions of immune cells.
The neutrophil-derived serine proteases cathepsin G and neutrophil elastase are implicated …

Allogeneic stem cell transplantation (SCT) is curative for hemophagocytic
lymphohistiocytosis (HLH). However, patients frequently have significant morbidity before …

Hemophagocytic syndrome (HS) is a severe and often fatal syndrome resulting from potent
and uncontrolled activation and proliferation of T‐lymphocytes, leading to excessive …

Granulysin, a molecule expressed by human natural killer cells and activated T lymphocytes,
exhibits cytolytic activity against a variety of microbes and tumors. Progress in understanding …

Allogeneic stem cell transplant is curative for haemophagocytic lymphohistiocytosis (HLH)
and refractory Langerhans cell histiocytosis (LCH). However, patients frequently have …

Granulysin and NK-lysin are antimicrobial proteins found in the granules of human and
swine cytotoxic lymphocytes. A murine counterpart to granulysin has not been identified to …

Granzymes are serine proteases mainly found in cytotoxic lymphocytes. The most-studied
member of this group is granzyme B, which is a potent cytotoxin that has set the paradigm …

Granzymes (Grz) are a family of serine proteases found in the granules of cytotoxic
lymphocytes and are emerging as an important group of proteins involved in immune …