Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Liver transplantation has been identified as the most effective treatment for patients with end-
stage liver diseases. However, hepatic ischemia reperfusion injury (IRI) is associated with …

Although alternative splicing (AS) drives transcriptional responses and cellular adaptation to
environmental stresses, its contributions in organ transplantation have not been …

Neutrophils, the largest innate immune cell population in humans, are the primary
proinflammatory sentinel in the ischemia-reperfusion injury (IRI) mechanism in orthotopic …

Abstract Sirtuin 1 (SIRT1) is a histone/protein deacetylase in the cellular response to
inflammatory, metabolic, and oxidative stressors. We previously reported that myeloid SIRT1 …

The innate immune system plays an essential role in the response to sterile inflammation
and its association with liver ischemia and reperfusion injury (IRI). Liver IRI often manifests …

Ameliorating graft injury induced by ischemia and hypoxia, expanding the donor pool, and
improving graft quality and recipient prognosis are still goals pursued by the transplant …

Background Although diabetes mellitus has been reported to aggravate liver ischaemia and
reperfusion (IR) injury, the basic mechanism remains largely unknown. The object of the …

Cerebral ischemia (CI), as the cerebrovascular disease with the highest incidence rate, is
treated by limited intravenous thrombolysis and intravascular therapy to recanalize the …

Although cold preservation remains the gold standard in organ transplantation, cold stress–
induced cellular injury is a significant problem in clinical orthotopic liver transplantation …