Background: To systematic review the efficacy and safety of 6-thioguanine (6-TG) in the
substitute of 6-mercaptopurine (6-MP) in the treatment for patients with childhood acute …

The imbalance between the proliferation and apoptosis of B-cell precursors is an important
contributor to the pathogenesis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) …

Acute lymphoblastic leukemia (ALL) represents a heterogeneous group of hematologic
malignancies, and it is normally characterized by an aberrant proliferation of immature …

This study aimed to analyse the characteristics and treatment outcomes of adult patients with
acute lymphoblastic leukaemia (ALL) and construct nomogram predictive models for …

Background The introduction of combined conventional cytostatics and pathway-specific
inhibitors has opened new treatment options for several cancer types including hematologic …

Little is known about optimally applying chemotherapeutic agents in a specific temporal
sequence to rapidly reduce the tumor load and to improve therapeutic efficacy. The clinical …

Introduction. microRNAs (miRNAs) are critical for tumorigenesis and progression of T-cell
acute lymphoblastic leukemia (T-ALL). MiR-96-5p has been shown to play important roles in …

As translocações cromossômicas são as principais alterações genéticas associadas com a
Leucemia Linfoide Aguda (LLA) e com a Leucemia Mieloide Aguda (LMA), sendo …

Objectives Ras-related dexamethasone-induced 1 (RASD1) is abnormally expressed in
many solid cancers. However, its potential role in adults with B-cell acute lymphoblastic …

Background: The introduction of combined conventional cytostatics and pathway‑specific
inhibitors has opened new treatment options for several cancer types including hematologic …